The effects of severe thermal- and pressure-transients on coated substrates with indentation-induced, blister defects were analyzed using experimental and finite-element methods. Both explicit and implicit FEA approaches were used to assess the transient thermal- and stress-states and the propensity for fracture related damage and evolution, while undergoing uniform convective heating and pressure transients across the surface. Spherical indentations along with in-situ acoustic emissions, c-scans, and finite element modeling were utilized to induce the defects, as well as quantify interfacial adhesion and cohesive zone properties. Preliminary results indicated complex interactions between the boundary conditions and their timing and the resulting propensity for damage birth and evolution. Given the need for robust coatings, the experimental and modeling procedures explored by this study will have important ramifications for coated tube designs and the evaluation of candidate materials.