Defining best practices for tissue procurement in immuno-oncology clinical trials: Consensus statement from the Society for Immunotherapy of Cancer Surgery Committee

Brian Gastman, Piyush K. Agarwal, Adam Berger, Genevieve Boland, Stephen Broderick, Lisa H. Butterfield, David Byrd, Peter E. Fecci, Robert L. Ferris, Yuman Fong, Stephanie L. Goff, Matthew M. Grabowski, Fumito Ito, Michael Lim, Michael T. Lotze, Haider Mahdi, Mokenge Malafa, Carol D. Morris, Pranav Murthy, Rogerio I. NevesAdekunle Odunsi, Sara I. Pai, Sangeetha Prabhakaran, Steven A. Rosenberg, Ragheed Saoud, Jyothi Sethuraman, Joseph Skitzki, Craig L. Slingluff, Vernon K. Sondak, John B. Sunwoo, Simon Turcotte, Cecilia C.S. Yeung, Howard L. Kaufman

Research output: Contribution to journalReview articlepeer-review

Abstract

Immunotherapy is now a cornerstone for cancer treatment, and much attention has been placed on the identification of prognostic and predictive biomarkers. The success of biomarker development is dependent on accurate and timely collection of biospecimens and high-quality processing, storage and shipping. Tumors are also increasingly used as source material for the generation of therapeutic T cells. There have been few guidelines or consensus statements on how to optimally collect and manage biospecimens and source material being used for immunotherapy and related research. The Society for Immunotherapy of Cancer Surgery Committee has brought together surgical experts from multiple subspecialty disciplines to identify best practices and to provide consensus on how best to access and manage specific tissues for immuno-oncology treatments and clinical investigation. In addition, the committee recommends early integration of surgeons and other interventional physicians with expertise in biospecimen collection, especially in clinical trials, to optimize the quality of tissue and the validity of correlative clinical studies in cancer immunotherapy.

Original languageEnglish (US)
Article number001583
JournalJournal for ImmunoTherapy of Cancer
Volume8
Issue number2
DOIs
StatePublished - Nov 16 2020

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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