Defining cross presentation for a wider audience

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Cross presentation is the process of production of peptide-MHC Class I complexes by cells in which the antigen that is the source of peptide is not translated. The majority of recent studies have described many facets of the classical TAP-dependent cross presentation pathway, but numerous pathways for transfer of antigenic material from a donor to a recipient cell followed by subsequent MHC-I-restricted presentation have been established, including transfer of protein antigen, peptide, RNA, DNA or even peptide-MHC-I complexes. The extent to which each of these pathways generates overlapping or unique peptide repertoires is unknown, as is the contribution of each of these pathways to generation of protective CD8+ T cells during infection or anti-tumor immune responses.

Original languageEnglish (US)
Pages (from-to)110-116
Number of pages7
JournalCurrent Opinion in Immunology
Volume40
DOIs
StatePublished - Jun 1 2016

Fingerprint

Cross-Priming
Peptides
Antigens
RNA
T-Lymphocytes
DNA
Infection
Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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abstract = "Cross presentation is the process of production of peptide-MHC Class I complexes by cells in which the antigen that is the source of peptide is not translated. The majority of recent studies have described many facets of the classical TAP-dependent cross presentation pathway, but numerous pathways for transfer of antigenic material from a donor to a recipient cell followed by subsequent MHC-I-restricted presentation have been established, including transfer of protein antigen, peptide, RNA, DNA or even peptide-MHC-I complexes. The extent to which each of these pathways generates overlapping or unique peptide repertoires is unknown, as is the contribution of each of these pathways to generation of protective CD8+ T cells during infection or anti-tumor immune responses.",
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Defining cross presentation for a wider audience. / Norbury, Christopher.

In: Current Opinion in Immunology, Vol. 40, 01.06.2016, p. 110-116.

Research output: Contribution to journalReview article

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AU - Norbury, Christopher

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