Defining the Lower Limit of a "critical Bone Defect" in Open Diaphyseal Tibial Fractures

Nikkole M. Haines, William D. Lack, Rachel B. Seymour, Michael J. Bosse

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Objectives: To determine healing outcomes of open diaphyseal tibial shaft fractures treated with reamed intramedullary nailing (IMN) with a bone gap of 10-50 mm on ≥50% of the cortical circumference and to better define a "critical bone defect" based on healing outcome. Design: Retrospective cohort study. Patients: Forty patients, age 18-65, with open diaphyseal tibial fractures with a bone gap of 10-50 mm on ≥50% of the circumference as measured on standard anteroposterior and lateral postoperative radiographs treated with IMN. Intervention: IMN of an open diaphyseal tibial fracture with a bone gap. Setting: Level-1 trauma center. Main Outcome Measurements: Healing outcomes, union or nonunion. Results: Forty patients were analyzed. Twenty-one (52.5%) went on to nonunion and nineteen (47.5%) achieved union. Radiographic apparent bone gap (RABG) and infection were the only 2 covariates predicting nonunion outcome (P 0.046 for infection). The RABG was determined by measuring the bone gap on each cortex and averaging over 4 cortices. Fractures achieving union had a RABG of 12 ± 1 mm versus 20 ± 2 mm in those going on to nonunion (P < 0.01). This remained significant when patients with infection were removed. Receiver operator characteristic analysis demonstrated that RABG was predictive of outcome (area under the curve of 0.79). A RABG of 25 mm was the statistically optimal threshold for prediction of healing outcome. Conclusions: Patients with open diaphyseal tibial fractures treated with IMN and a <25 mm RABG have a reasonable probability of achieving union without additional intervention, whereas those with larger gaps have a higher probability of nonunion. Research investigating interventions for RABGs should use a predictive threshold for defining a critical bone defect that is associated with greater than 50% risk of nonunion without supplementary treatment. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

Original languageEnglish (US)
Pages (from-to)e158-e163
JournalJournal of orthopaedic trauma
Issue number5
StatePublished - May 1 2016

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine


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