Delayed distribution of active vasodilation and altered vascular conductance in aged skin

Jane M. Pierzga, Adam Frymoyer, W. Larry Kenney

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Reflex vasodilation is attenuated in aged skin during hyperthermia. We used laser-Doppler imaging (LDI) to test the hypothesis that the magnitude of conductance and the spatial distribution of vasodilation are altered with aging. LDI of forearm skin was compared in 12 young (19- to 29-yr-old) and 12 older (64- to 75-yr-old) men during supine passive heating. Additionally, iontophoresis of bretylium tosylate was performed in a subset of subjects to explore the involvement of sympathetic vasoconstriction in limiting skin blood flow. Passive heating with water-perfused suits clamped mean skin temperature at 41.0 ± 0.5°C, causing a ramp increase in esophageal temperature (Tes) to ≤38.5°C. LDI scans were performed at baseline and at every 0.2°C increase in Tes. LDI at bretylium and control sites was identical, suggesting no influence of noradrenergic vasoconstriction. Forearm vascular conductance (venous occlusion plethysmography) was reduced in the older men (P ≤ 0.001) at every elevated Tes. Mean cutaneous vascular conductance (CVC) of the scanned area was reduced in the older men at 0.2°C ≤ ΔTes ≤ 0.8°C. Early in heating (0.2°C ≤ ΔTes ≤ 0.6°C), older men also responded with a reduced vasodilated area (P ≤ 0.05), implying a slower recruitment or filling of skin microvessels. The results indicate that the area of vasodilation and CVC within the vasodilated area are reduced in aged skin during early passive heating, but only CVC is reduced at ΔTes = 0.8°C.

Original languageEnglish (US)
Pages (from-to)1045-1053
Number of pages9
JournalJournal of applied physiology
Volume94
Issue number3
DOIs
StatePublished - Mar 1 2003

Fingerprint

Vasodilation
Blood Vessels
Skin
Heating
Lasers
Vasoconstriction
Forearm
Bretylium Tosylate
Iontophoresis
Architectural Accessibility
Plethysmography
Skin Temperature
Microvessels
Reflex
Fever
Temperature
Water

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

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abstract = "Reflex vasodilation is attenuated in aged skin during hyperthermia. We used laser-Doppler imaging (LDI) to test the hypothesis that the magnitude of conductance and the spatial distribution of vasodilation are altered with aging. LDI of forearm skin was compared in 12 young (19- to 29-yr-old) and 12 older (64- to 75-yr-old) men during supine passive heating. Additionally, iontophoresis of bretylium tosylate was performed in a subset of subjects to explore the involvement of sympathetic vasoconstriction in limiting skin blood flow. Passive heating with water-perfused suits clamped mean skin temperature at 41.0 ± 0.5°C, causing a ramp increase in esophageal temperature (Tes) to ≤38.5°C. LDI scans were performed at baseline and at every 0.2°C increase in Tes. LDI at bretylium and control sites was identical, suggesting no influence of noradrenergic vasoconstriction. Forearm vascular conductance (venous occlusion plethysmography) was reduced in the older men (P ≤ 0.001) at every elevated Tes. Mean cutaneous vascular conductance (CVC) of the scanned area was reduced in the older men at 0.2°C ≤ ΔTes ≤ 0.8°C. Early in heating (0.2°C ≤ ΔTes ≤ 0.6°C), older men also responded with a reduced vasodilated area (P ≤ 0.05), implying a slower recruitment or filling of skin microvessels. The results indicate that the area of vasodilation and CVC within the vasodilated area are reduced in aged skin during early passive heating, but only CVC is reduced at ΔTes = 0.8°C.",
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Delayed distribution of active vasodilation and altered vascular conductance in aged skin. / Pierzga, Jane M.; Frymoyer, Adam; Kenney, W. Larry.

In: Journal of applied physiology, Vol. 94, No. 3, 01.03.2003, p. 1045-1053.

Research output: Contribution to journalArticle

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