Delayed sequelae after acute overdoses or poisonings: Cranial neuropathy related to ethylene glycol ingestion

Lionel D. Lewis, Brian W. Smith, Alexander Mamourian

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A 31-year-old woman came to the hospital with breathlessness, confusion, and a refractory anion gap metabolic acidosis; acute renal failure subsequently developed. Her blood ethylene glycol concentration was 390 mg/L, and she was treated with an intravenous ethanol infusion and hemodialysis. During the tenth and eleventh day after admission bilateral seventh cranial nerve paralysis developed, as well as bilateral dysfunction of cranial nerves II, V, VIII, IX, X, and XII. Magnetic resonance imaging of her head showed gadolinium enhancement of the fifth cranial nerve bilaterally and a communicating hydrocephalus. Over the subsequent 11 months she recovered full function of her cranial nerves V, VII, IX, X, and XII, and she had subjective clinical improvement to baseline function in cranial nerves II and VIII. This case serves to introduce a discussion of agents that cause delayed complications after their acute toxic ingestion.

Original languageEnglish (US)
Pages (from-to)692-699
Number of pages8
JournalClinical pharmacology and therapeutics
Volume61
Issue number6
DOIs
StatePublished - Jun 1 1997

Fingerprint

Cranial Nerve Diseases
Trigeminal Nerve
Ethylene Glycol
Poisoning
Eating
Facial Nerve
Optic Nerve
Vestibulocochlear Nerve
Acid-Base Equilibrium
Poisons
Gadolinium
Hydrocephalus
Acidosis
Acute Kidney Injury
Intravenous Infusions
Paralysis
Dyspnea
Renal Dialysis
Ethanol
Head

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

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Delayed sequelae after acute overdoses or poisonings : Cranial neuropathy related to ethylene glycol ingestion. / Lewis, Lionel D.; Smith, Brian W.; Mamourian, Alexander.

In: Clinical pharmacology and therapeutics, Vol. 61, No. 6, 01.06.1997, p. 692-699.

Research output: Contribution to journalArticle

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