Abstract
We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2-/- (also known as Kcnh3-/-) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.
Original language | English (US) |
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Pages (from-to) | 1056-1058 |
Number of pages | 3 |
Journal | Nature Neuroscience |
Volume | 13 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2010 |
All Science Journal Classification (ASJC) codes
- Neuroscience(all)