Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy

Xiaofei Zhang, Federica Bertaso, Jong W. Yoo, Karsten Baumgärtel, Sinead M. Clancy, Van Lee, Cynthia Cienfuegos, Carly Wilmot, Jacqueline Avis, Truc Hunyh, Catherine Daguia, Christian Schmedt, Jeffrey Noebels, Timothy Jegla

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2-/- (also known as Kcnh3-/-) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.

Original languageEnglish (US)
Pages (from-to)1056-1058
Number of pages3
JournalNature Neuroscience
Volume13
Issue number9
DOIs
StatePublished - Sep 2010

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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