Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy

Xiaofei Zhang; Federica Bertaso; Jong W. Yoo; Karsten Baumgärtel; Sinead M. Clancy; Van Lee; Cynthia Cienfuegos; Carly Wilmot; Jacqueline Avis; Truc Hunyh; Catherine Daguia; Christian Schmedt; Jeffrey Noebels; Timothy Jegla

doi:10.1038/nn.2610

Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy

Xiaofei Zhang, Federica Bertaso, Jong W. Yoo, Karsten Baumgärtel, Sinead M. Clancy, Van Lee, Cynthia Cienfuegos, Carly Wilmot, Jacqueline Avis, Truc Hunyh, Catherine Daguia, Christian Schmedt, Jeffrey Noebels, Timothy Jegla

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

We found the voltage-gated K⁺ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2^-/- (also known as Kcnh3^-/-) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.

Original language	English (US)
Pages (from-to)	1056-1058
Number of pages	3
Journal	Nature Neuroscience
Volume	13
Issue number	9
DOIs	https://doi.org/10.1038/nn.2610
State	Published - Sep 2010

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1038/nn.2610

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Zhang, Xiaofei ; Bertaso, Federica ; Yoo, Jong W. ; Baumgärtel, Karsten ; Clancy, Sinead M. ; Lee, Van ; Cienfuegos, Cynthia ; Wilmot, Carly ; Avis, Jacqueline ; Hunyh, Truc ; Daguia, Catherine ; Schmedt, Christian ; Noebels, Jeffrey ; Jegla, Timothy. / Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. In: Nature Neuroscience. 2010 ; Vol. 13, No. 9. pp. 1056-1058.

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abstract = "We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2-/- (also known as Kcnh3-/-) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.",

author = "Xiaofei Zhang and Federica Bertaso and Yoo, {Jong W.} and Karsten Baumg{\"a}rtel and Clancy, {Sinead M.} and Van Lee and Cynthia Cienfuegos and Carly Wilmot and Jacqueline Avis and Truc Hunyh and Catherine Daguia and Christian Schmedt and Jeffrey Noebels and Timothy Jegla",

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Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. / Zhang, Xiaofei; Bertaso, Federica; Yoo, Jong W.; Baumgärtel, Karsten; Clancy, Sinead M.; Lee, Van; Cienfuegos, Cynthia; Wilmot, Carly; Avis, Jacqueline; Hunyh, Truc; Daguia, Catherine; Schmedt, Christian; Noebels, Jeffrey; Jegla, Timothy.

In: Nature Neuroscience, Vol. 13, No. 9, 09.2010, p. 1056-1058.

Research output: Contribution to journal › Article › peer-review

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