Delineating 3D angiogenic sprouting in OCT images via multiple active contours

Ting Xu, Fengqiang Li, Duc Huy T. Nguyen, Christopher S. Chen, Chao Zhou, Xiaolei Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Recent advances in Optical Coherence Tomography (OCT) has enabled high resolution imaging of three dimensional artificial vascular networks in vitro. Image segmentation can help quantify the morphological and topological properties of these curvilinear networks to facilitate quantitative study of the angiogenic process. Here we present a novel method to delineate the 3D artificial vascular networks imaged by spectral-domain OCT. Our method employs multiple Stretching Open Active Contours (SOACs) that evolve synergistically to retrieve both the morphology and topology of the underlying vascular networks. Quantification of the network properties can then be conducted based on the segmentation result. We demonstrate the potential of the proposed method by segmenting 3D artificial vasculature in simulated and real OCT images. We provide junction locations and vessel lengths as examples for quantifying angiogenic sprouting of 3D artificial vasculature from OCT images.

Original languageEnglish (US)
Title of host publicationAugmented Reality Environments for Medical Imaging and Computer-Assisted Interventions - 6th Int. Workshop, MIAR 2013 and 8th Int. Workshop, AE-CAI 2013, Held in Conjunction with MICCAI 2013, Proc.
Pages231-240
Number of pages10
DOIs
StatePublished - 2013
Event6th International Workshop on Augmented Reality Environments for Medical Imaging and Computer-Assisted Interventions, MIAR 2013 and 8th International Workshop, AE-CAI 2013, Held in Conjunction with MICCAI 2013 - Nagoya, Japan
Duration: Sep 22 2013Sep 22 2013

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8090 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference6th International Workshop on Augmented Reality Environments for Medical Imaging and Computer-Assisted Interventions, MIAR 2013 and 8th International Workshop, AE-CAI 2013, Held in Conjunction with MICCAI 2013
CountryJapan
CityNagoya
Period9/22/139/22/13

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

Fingerprint Dive into the research topics of 'Delineating 3D angiogenic sprouting in OCT images via multiple active contours'. Together they form a unique fingerprint.

Cite this