Delivery of Tea Polyphenols to the Oral Cavity by Green Tea Leaves and Black Tea Extract

Mao Jung Lee, Joshua D. Lambert, Saileta Prabhu, Xiaofeng Meng, Hong Lu, Pius Maliakal, Chi Tang Ho, Chung S. Yang

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Catechins and theaflavins, polyphenolic compounds derived from tea (Camellia sinensis, fam. Theaceae), have been reported to have a wide range of biological activities including prevention of tooth decay and oral cancer. The present study was undertaken to determine the usefulness of green tea leaves and black tea extract for the delivery of catechins and theaflavins to the oral cavity. After holding either green tea leaves (2 g) or brewed black tea (2 g of black tea leaves in 100 mi) in the mouth for 2-5 min and thoroughly rinsing the mouth, high concentrations of catechins (Cmax = 131.0-2.2 μM) and theaflavins (Cmax = 1.8-0.6 μM) were observed in saliva in the 1st hour. Whereas there was significant interindividual variation in the peak levels of catechins and theaflavins, the overall kinetic profile was similar, with t1/2 = 25-44 min and 49-76 min for catechins and theaflavins, respectively (average coefficient of variation in t1/2 was 23.4%). In addition to the parent catechin and theaflavin peaks, five unidentified peaks were also observed in saliva after black tea treatment. Hydrolysis of theaflavin gallates, apparently by salivary esterases, was observed in vitro and in vivo. These results indicate that tea leaves can be used as a convenient, slow-release source of catechins and theaflavins and provide information for the possible use of tea in the prevention of oral cancer and dental caries.

Original languageEnglish (US)
Pages (from-to)132-137
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2004

Fingerprint

Polyphenols
Tea
Catechin
Mouth
Mouth Neoplasms
Saliva
Theaceae
Camellia sinensis
Dental Caries
Esterases
theaflavin
Tooth
Hydrolysis

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Lee, Mao Jung ; Lambert, Joshua D. ; Prabhu, Saileta ; Meng, Xiaofeng ; Lu, Hong ; Maliakal, Pius ; Ho, Chi Tang ; Yang, Chung S. / Delivery of Tea Polyphenols to the Oral Cavity by Green Tea Leaves and Black Tea Extract. In: Cancer Epidemiology Biomarkers and Prevention. 2004 ; Vol. 13, No. 1. pp. 132-137.
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abstract = "Catechins and theaflavins, polyphenolic compounds derived from tea (Camellia sinensis, fam. Theaceae), have been reported to have a wide range of biological activities including prevention of tooth decay and oral cancer. The present study was undertaken to determine the usefulness of green tea leaves and black tea extract for the delivery of catechins and theaflavins to the oral cavity. After holding either green tea leaves (2 g) or brewed black tea (2 g of black tea leaves in 100 mi) in the mouth for 2-5 min and thoroughly rinsing the mouth, high concentrations of catechins (Cmax = 131.0-2.2 μM) and theaflavins (Cmax = 1.8-0.6 μM) were observed in saliva in the 1st hour. Whereas there was significant interindividual variation in the peak levels of catechins and theaflavins, the overall kinetic profile was similar, with t1/2 = 25-44 min and 49-76 min for catechins and theaflavins, respectively (average coefficient of variation in t1/2 was 23.4{\%}). In addition to the parent catechin and theaflavin peaks, five unidentified peaks were also observed in saliva after black tea treatment. Hydrolysis of theaflavin gallates, apparently by salivary esterases, was observed in vitro and in vivo. These results indicate that tea leaves can be used as a convenient, slow-release source of catechins and theaflavins and provide information for the possible use of tea in the prevention of oral cancer and dental caries.",
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Delivery of Tea Polyphenols to the Oral Cavity by Green Tea Leaves and Black Tea Extract. / Lee, Mao Jung; Lambert, Joshua D.; Prabhu, Saileta; Meng, Xiaofeng; Lu, Hong; Maliakal, Pius; Ho, Chi Tang; Yang, Chung S.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 13, No. 1, 01.01.2004, p. 132-137.

Research output: Contribution to journalArticle

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