Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy

Alexandros Vgontzas, Theodore C. Friedman, George P. Chrousos, Edward Bixler, Antonio Vela-Bueno, Anthony Kales

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We measured morning plasma concentrations of delta sleep-inducing-peptide-like-immunoreactivity (DSIP-LI) in 9 sleep apnea patients, 10 narcolepsy patients, and 11 normal controls. Comparisons between the three groups showed no significant differences, although there was a trend toward association with low levels of DSIP-LI in the narcoleptic group, particularly in patients not using medications. No differences were found in the morning or evening plasma DSIP-LI levels in a second group of 11 normal controls and 8 sleep apneics. Our findings do not appear to support a biological marker role of disease activity for single measures of plasma DSIP in sleep apnea.

Original languageEnglish (US)
Pages (from-to)1153-1156
Number of pages4
JournalPeptides
Volume16
Issue number6
DOIs
StatePublished - Jan 1 1995

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Delta Sleep-Inducing Peptide
Narcolepsy
Sleep Apnea Syndromes
Plasmas
Sleep
Biomarkers

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Vgontzas, A., Friedman, T. C., Chrousos, G. P., Bixler, E., Vela-Bueno, A., & Kales, A. (1995). Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy. Peptides, 16(6), 1153-1156. https://doi.org/10.1016/0196-9781(95)00092-X
Vgontzas, Alexandros ; Friedman, Theodore C. ; Chrousos, George P. ; Bixler, Edward ; Vela-Bueno, Antonio ; Kales, Anthony. / Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy. In: Peptides. 1995 ; Vol. 16, No. 6. pp. 1153-1156.
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Vgontzas, A, Friedman, TC, Chrousos, GP, Bixler, E, Vela-Bueno, A & Kales, A 1995, 'Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy', Peptides, vol. 16, no. 6, pp. 1153-1156. https://doi.org/10.1016/0196-9781(95)00092-X

Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy. / Vgontzas, Alexandros; Friedman, Theodore C.; Chrousos, George P.; Bixler, Edward; Vela-Bueno, Antonio; Kales, Anthony.

In: Peptides, Vol. 16, No. 6, 01.01.1995, p. 1153-1156.

Research output: Contribution to journalArticle

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