TY - JOUR
T1 - Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy
AU - Vgontzas, Alexandros N.
AU - Friedman, Theodore C.
AU - Chrousos, George P.
AU - Bixler, Edward O.
AU - Vela-Bueno, Antonio
AU - Kales, Anthony
PY - 1995
Y1 - 1995
N2 - We measured morning plasma concentrations of delta sleep-inducing-peptide-like-immunoreactivity (DSIP-LI) in 9 sleep apnea patients, 10 narcolepsy patients, and 11 normal controls. Comparisons between the three groups showed no significant differences, although there was a trend toward association with low levels of DSIP-LI in the narcoleptic group, particularly in patients not using medications. No differences were found in the morning or evening plasma DSIP-LI levels in a second group of 11 normal controls and 8 sleep apneics. Our findings do not appear to support a biological marker role of disease activity for single measures of plasma DSIP in sleep apnea.
AB - We measured morning plasma concentrations of delta sleep-inducing-peptide-like-immunoreactivity (DSIP-LI) in 9 sleep apnea patients, 10 narcolepsy patients, and 11 normal controls. Comparisons between the three groups showed no significant differences, although there was a trend toward association with low levels of DSIP-LI in the narcoleptic group, particularly in patients not using medications. No differences were found in the morning or evening plasma DSIP-LI levels in a second group of 11 normal controls and 8 sleep apneics. Our findings do not appear to support a biological marker role of disease activity for single measures of plasma DSIP in sleep apnea.
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U2 - 10.1016/0196-9781(95)00092-X
DO - 10.1016/0196-9781(95)00092-X
M3 - Article
C2 - 8532601
AN - SCOPUS:0029150041
VL - 16
SP - 1153
EP - 1156
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 6
ER -