Abstract
We measured morning plasma concentrations of delta sleep-inducing-peptide-like-immunoreactivity (DSIP-LI) in 9 sleep apnea patients, 10 narcolepsy patients, and 11 normal controls. Comparisons between the three groups showed no significant differences, although there was a trend toward association with low levels of DSIP-LI in the narcoleptic group, particularly in patients not using medications. No differences were found in the morning or evening plasma DSIP-LI levels in a second group of 11 normal controls and 8 sleep apneics. Our findings do not appear to support a biological marker role of disease activity for single measures of plasma DSIP in sleep apnea.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1153-1156 |
| Number of pages | 4 |
| Journal | Peptides |
| Volume | 16 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1995 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Physiology
- Endocrinology
- Cellular and Molecular Neuroscience
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Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy. / Vgontzas, Alexandros; Friedman, Theodore C.; Chrousos, George P.; Bixler, Edward; Vela-Bueno, Antonio; Kales, Anthony.
In: Peptides, Vol. 16, No. 6, 01.01.1995, p. 1153-1156.Research output: Contribution to journal › Article
TY - JOUR
T1 - Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy
AU - Vgontzas, Alexandros
AU - Friedman, Theodore C.
AU - Chrousos, George P.
AU - Bixler, Edward
AU - Vela-Bueno, Antonio
AU - Kales, Anthony
PY - 1995/1/1
Y1 - 1995/1/1
N2 - We measured morning plasma concentrations of delta sleep-inducing-peptide-like-immunoreactivity (DSIP-LI) in 9 sleep apnea patients, 10 narcolepsy patients, and 11 normal controls. Comparisons between the three groups showed no significant differences, although there was a trend toward association with low levels of DSIP-LI in the narcoleptic group, particularly in patients not using medications. No differences were found in the morning or evening plasma DSIP-LI levels in a second group of 11 normal controls and 8 sleep apneics. Our findings do not appear to support a biological marker role of disease activity for single measures of plasma DSIP in sleep apnea.
AB - We measured morning plasma concentrations of delta sleep-inducing-peptide-like-immunoreactivity (DSIP-LI) in 9 sleep apnea patients, 10 narcolepsy patients, and 11 normal controls. Comparisons between the three groups showed no significant differences, although there was a trend toward association with low levels of DSIP-LI in the narcoleptic group, particularly in patients not using medications. No differences were found in the morning or evening plasma DSIP-LI levels in a second group of 11 normal controls and 8 sleep apneics. Our findings do not appear to support a biological marker role of disease activity for single measures of plasma DSIP in sleep apnea.
UR - http://www.scopus.com/inward/record.url?scp=0029150041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029150041&partnerID=8YFLogxK
U2 - 10.1016/0196-9781(95)00092-X
DO - 10.1016/0196-9781(95)00092-X
M3 - Article
C2 - 8532601
AN - SCOPUS:0029150041
VL - 16
SP - 1153
EP - 1156
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 6
ER -