Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy

Alexandros N. Vgontzas, Theodore C. Friedman, George P. Chrousos, Edward O. Bixler, Antonio Vela-Bueno, Anthony Kales

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We measured morning plasma concentrations of delta sleep-inducing-peptide-like-immunoreactivity (DSIP-LI) in 9 sleep apnea patients, 10 narcolepsy patients, and 11 normal controls. Comparisons between the three groups showed no significant differences, although there was a trend toward association with low levels of DSIP-LI in the narcoleptic group, particularly in patients not using medications. No differences were found in the morning or evening plasma DSIP-LI levels in a second group of 11 normal controls and 8 sleep apneics. Our findings do not appear to support a biological marker role of disease activity for single measures of plasma DSIP in sleep apnea.

Original languageEnglish (US)
Pages (from-to)1153-1156
Number of pages4
JournalPeptides
Volume16
Issue number6
DOIs
StatePublished - 1995

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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