Dendrite injury triggers DLK-independent regeneration

Michelle C. Stone, Richard M. Albertson, Li Chen, Melissa Rolls

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Axon injury triggers regeneration through activation of a conserved kinase cascade, which includes the dual leucine zipper kinase (DLK). Although dendrites are damaged during stroke, traumatic brain injury, and seizure, it is not known whether mature neurons monitor dendrite injury and initiate regeneration. We probed the response to dendrite damage using model Drosophila neurons. Two larval neuron types regrew dendrites in distinct ways after all dendrites were removed. Dendrite regeneration was also triggered by injury in adults. Next, we tested whetherdendrite injury was initiated with the same machinery as axon injury. Surprisingly, DLK, JNK, and fos were dispensable for dendrite regeneration. Moreover, this MAP kinase pathway was not activated by injury to dendrites. Thus, neurons respond to dendrite damage and initiate regeneration without using the conserved DLK cascade that triggers axon regeneration.

Original languageEnglish (US)
Pages (from-to)247-253
Number of pages7
JournalCell Reports
Volume6
Issue number2
DOIs
StatePublished - Jan 10 2014

Fingerprint

Leucine Zippers
Dendrites
Neurons
Regeneration
Phosphotransferases
Wounds and Injuries
MAP Kinase Kinase 4
Axons
Machinery
Brain
Chemical activation
Drosophila
Seizures
Stroke

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Stone, Michelle C. ; Albertson, Richard M. ; Chen, Li ; Rolls, Melissa. / Dendrite injury triggers DLK-independent regeneration. In: Cell Reports. 2014 ; Vol. 6, No. 2. pp. 247-253.
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Dendrite injury triggers DLK-independent regeneration. / Stone, Michelle C.; Albertson, Richard M.; Chen, Li; Rolls, Melissa.

In: Cell Reports, Vol. 6, No. 2, 10.01.2014, p. 247-253.

Research output: Contribution to journalArticle

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