Dendritic Cell Regulation of Graft Vs.-Host Disease: Immunostimulation and Tolerance Immunostimulation

Hongshuang Yu, Yuanyuan Tian, Ying Wang, Shin Mineishi, Yi Zhang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Graft-vs.-host disease (GVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Significant progresses have been made in defining the dichotomous role of dendritic cells (DCs) in the development of GVHD. Host-derived DCs are important to elicit allogeneic T cell responses, whereas certain donor-types of DCs derived from newly engrafted hematopoietic stem/progenitor cells (HSPCs) can amply this graft-vs.-host reaction. In contrast, some DCs also play non-redundant roles in mediating immune tolerance. They induce apoptotic deletion of host-reactive donor T cells while promoting expansion and function of regulatory T cells (Treg). Unfortunately, this tolerogenic effect of DCs is impaired during GVHD. Severe GVHD in patients subject to allo-HSCT is associated with significantly decreased number of circulating peripheral blood DCs during engraftment. Existing studies reveal that GVHD causes delayed reconstitution of donor DCs from engrafted HSPCs, impairs the antigen presentation function of newly generated DCs and reduces the capacity of DCs to regulate Treg. The present review will discuss the importance of DCs in alloimmunity and the mechanism underlying DC reconstitution after allo-HSCT.

Original languageEnglish (US)
Article number93
JournalFrontiers in immunology
Volume10
Issue numberFEB
DOIs
StatePublished - Jan 1 2019

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Dendritic Cells
Immunization
Transplants
Hematopoietic Stem Cells
Hematopoietic Stem Cell Transplantation
Tissue Donors
T-Lymphocytes
Immune Tolerance
Antigen Presentation
Regulatory T-Lymphocytes
Blood Cells
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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abstract = "Graft-vs.-host disease (GVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Significant progresses have been made in defining the dichotomous role of dendritic cells (DCs) in the development of GVHD. Host-derived DCs are important to elicit allogeneic T cell responses, whereas certain donor-types of DCs derived from newly engrafted hematopoietic stem/progenitor cells (HSPCs) can amply this graft-vs.-host reaction. In contrast, some DCs also play non-redundant roles in mediating immune tolerance. They induce apoptotic deletion of host-reactive donor T cells while promoting expansion and function of regulatory T cells (Treg). Unfortunately, this tolerogenic effect of DCs is impaired during GVHD. Severe GVHD in patients subject to allo-HSCT is associated with significantly decreased number of circulating peripheral blood DCs during engraftment. Existing studies reveal that GVHD causes delayed reconstitution of donor DCs from engrafted HSPCs, impairs the antigen presentation function of newly generated DCs and reduces the capacity of DCs to regulate Treg. The present review will discuss the importance of DCs in alloimmunity and the mechanism underlying DC reconstitution after allo-HSCT.",
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Dendritic Cell Regulation of Graft Vs.-Host Disease : Immunostimulation and Tolerance Immunostimulation. / Yu, Hongshuang; Tian, Yuanyuan; Wang, Ying; Mineishi, Shin; Zhang, Yi.

In: Frontiers in immunology, Vol. 10, No. FEB, 93, 01.01.2019.

Research output: Contribution to journalArticle

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