Dendroamides, new cyclic hexapeptides from a blue-green alga. Multidrug- resistance reversing activity of dendroamide A

Junichi Ogino, Richard E. Moore, Gregory M.L. Patterson, Charles D. Smith

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Dendroamide A (1), one of three new bistratamide-type cyclic hexapeptides from the terrestrial blue-green alga (cyanobacterium) Stigonema dendroideum Fremy, exhibits multidrug-resistance reversing activity. The gross structures of the three compounds, dendroamides A-C, were determined by NMR and mass spectral analyses. Their absolute stereochemistries were determined by Marfey and chiral GC/MS analyses of derivatives formed from acid hydrolysis of the intact and ozonized peptides.

Original languageEnglish (US)
Pages (from-to)581-586
Number of pages6
JournalJournal of Natural Products
Issue number6
StatePublished - Jun 1 1996


All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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