Depression and Executive Functioning Bidirectionally Impair One Another across 9 Years: Evidence from Within-Person Latent Change and Cross-Lagged Models

Nur Hani Zainal, Michelle G. Newman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Scar and vulnerability models assert that increased psychopathology may predict subsequent executive functioning deficits (and vice versa) over protracted timescales, yet most prior work on this topic has been cross-sectional. Thus, we tested the within- and between-person relations between EF, depression and anxiety. Method: Older adult participants (n = 856) were assessed across 4 waves, approximately 2 years apart. Performance-based EF and caregiver-rated symptom measures were administered. Bivariate latent change score and random-intercept cross-lagged panel models were conducted. Results: Within persons, RI-CLPMs revealed that prior greater depression forecasted lower subsequent EF, and vice versa (d = -0.292 vs. -0.292). BCS models showed that within-person rise in depression predicted EF decreases, and vice versa (d = -0.245 vs. -0.245). No within-person, cross-lagged, EF-anxiety relations emerged. Further, significant negative between-person EF-symptom relations were observed (d = -0.264 -0.395). Discussion: Prospective, within-person findings offer some evidence for developmental scar and vulnerability models.

Original languageEnglish (US)
JournalEuropean Psychiatry
DOIs
StateAccepted/In press - 2021

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

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