Der Haupthistokompatibilitätskomplex und die Unterscheidung zwischen Selbst und Fremd durch das Immunsystem

Jan Klein, Hans Georg Rammensee, Zoltan A. Nagy

Research output: Contribution to journalArticle

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Abstract

The major histocompatibility complex (Mhc) is a cluster of closely linked genes which are involved in the distinction between self and non-self. The genes fall into two classes, I and II, which are evolutionarily related but specialized to performing somewhat different functions. The Mhc genes code for proteins which are seen together with foreign substances by the thymus-derived lymphocytes. These lymphocytes thus recognize simultaneously self (Mhc molecules) and non-self (foreign antigen). Some of the Mhc genes are highly polymorphic and this polymorphism probably represents a compensation for the fact that certain combinations of Mhc molecules and antigen fail to be recognized by the T lymphocyte.

Original languageGerman
Pages (from-to)265-271
Number of pages7
JournalNaturwissenschaften
Volume70
Issue number6
DOIs
Publication statusPublished - Jun 1983

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

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