Der Haupthistokompatibilitätskomplex und die Unterscheidung zwischen Selbst und Fremd durch das Immunsystem

Jan Klein, Hans Georg Rammensee, Zoltan A. Nagy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The major histocompatibility complex (Mhc) is a cluster of closely linked genes which are involved in the distinction between self and non-self. The genes fall into two classes, I and II, which are evolutionarily related but specialized to performing somewhat different functions. The Mhc genes code for proteins which are seen together with foreign substances by the thymus-derived lymphocytes. These lymphocytes thus recognize simultaneously self (Mhc molecules) and non-self (foreign antigen). Some of the Mhc genes are highly polymorphic and this polymorphism probably represents a compensation for the fact that certain combinations of Mhc molecules and antigen fail to be recognized by the T lymphocyte.

Original languageGerman
Pages (from-to)265-271
Number of pages7
JournalNaturwissenschaften
Volume70
Issue number6
DOIs
StatePublished - Jan 1 1983

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

Cite this

Klein, Jan ; Rammensee, Hans Georg ; Nagy, Zoltan A. / Der Haupthistokompatibilitätskomplex und die Unterscheidung zwischen Selbst und Fremd durch das Immunsystem. In: Naturwissenschaften. 1983 ; Vol. 70, No. 6. pp. 265-271.
@article{3b9a561930fe48c9baf78339b50b0a4c,
title = "Der Haupthistokompatibilit{\"a}tskomplex und die Unterscheidung zwischen Selbst und Fremd durch das Immunsystem",
abstract = "The major histocompatibility complex (Mhc) is a cluster of closely linked genes which are involved in the distinction between self and non-self. The genes fall into two classes, I and II, which are evolutionarily related but specialized to performing somewhat different functions. The Mhc genes code for proteins which are seen together with foreign substances by the thymus-derived lymphocytes. These lymphocytes thus recognize simultaneously self (Mhc molecules) and non-self (foreign antigen). Some of the Mhc genes are highly polymorphic and this polymorphism probably represents a compensation for the fact that certain combinations of Mhc molecules and antigen fail to be recognized by the T lymphocyte.",
author = "Jan Klein and Rammensee, {Hans Georg} and Nagy, {Zoltan A.}",
year = "1983",
month = "1",
day = "1",
doi = "10.1007/BF00404832",
language = "German",
volume = "70",
pages = "265--271",
journal = "Die Naturwissenschaften",
issn = "0028-1042",
publisher = "Springer Verlag",
number = "6",

}

Der Haupthistokompatibilitätskomplex und die Unterscheidung zwischen Selbst und Fremd durch das Immunsystem. / Klein, Jan; Rammensee, Hans Georg; Nagy, Zoltan A.

In: Naturwissenschaften, Vol. 70, No. 6, 01.01.1983, p. 265-271.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Der Haupthistokompatibilitätskomplex und die Unterscheidung zwischen Selbst und Fremd durch das Immunsystem

AU - Klein, Jan

AU - Rammensee, Hans Georg

AU - Nagy, Zoltan A.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - The major histocompatibility complex (Mhc) is a cluster of closely linked genes which are involved in the distinction between self and non-self. The genes fall into two classes, I and II, which are evolutionarily related but specialized to performing somewhat different functions. The Mhc genes code for proteins which are seen together with foreign substances by the thymus-derived lymphocytes. These lymphocytes thus recognize simultaneously self (Mhc molecules) and non-self (foreign antigen). Some of the Mhc genes are highly polymorphic and this polymorphism probably represents a compensation for the fact that certain combinations of Mhc molecules and antigen fail to be recognized by the T lymphocyte.

AB - The major histocompatibility complex (Mhc) is a cluster of closely linked genes which are involved in the distinction between self and non-self. The genes fall into two classes, I and II, which are evolutionarily related but specialized to performing somewhat different functions. The Mhc genes code for proteins which are seen together with foreign substances by the thymus-derived lymphocytes. These lymphocytes thus recognize simultaneously self (Mhc molecules) and non-self (foreign antigen). Some of the Mhc genes are highly polymorphic and this polymorphism probably represents a compensation for the fact that certain combinations of Mhc molecules and antigen fail to be recognized by the T lymphocyte.

UR - http://www.scopus.com/inward/record.url?scp=0020642990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020642990&partnerID=8YFLogxK

U2 - 10.1007/BF00404832

DO - 10.1007/BF00404832

M3 - Article

C2 - 6603580

AN - SCOPUS:0020642990

VL - 70

SP - 265

EP - 271

JO - Die Naturwissenschaften

JF - Die Naturwissenschaften

SN - 0028-1042

IS - 6

ER -