Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European

Iñigo Olalde, Morten E. Allentoft, Federico Sánchez-Quinto, Gabriel Santpere, Charleston W.K. Chiang, Michael DeGiorgio, Javier Prado-Martinez, Juan Antonio Rodríguez, Simon Rasmussen, Javier Quilez, Oscar Ramírez, Urko M. Marigorta, Marcos Fernández-Callejo, María Encina Prada, Julio Manuel Vidal Encinas, Rasmus Nielsen, Mihai G. Netea, John Novembre, Richard A. Sturm, Pardis SabetiTomàs Marquès-Bonet, Arcadi Navarro, Eske Willerslev, Carles Lalueza-Fox

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Ancient genomic sequences have started to reveal the origin and the demographic impact of farmers from the Neolithic period spreading into Europe. The adoption of farming, stock breeding and sedentary societies during the Neolithic may have resulted in adaptive changes in genes associated with immunity and diet. However, the limited data available from earlier hunter-gatherers preclude an understanding of the selective processes associated with this crucial transition to agriculture in recent human evolution. Here we sequence an approximately 7,000-year-old Mesolithic skeleton discovered at the La Braña-Arintero site in León, Spain, to retrieve a complete pre-agricultural European human genome. Analysis of this genome in the context of other ancient samples suggests the existence of a common ancient genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic. The La Braña individual carries ancestral alleles in several skin pigmentation genes, suggesting that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times. Moreover, we provide evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalNature
Volume507
Issue number7491
DOIs
StatePublished - Jan 1 2014

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Pigmentation
Agriculture
Alleles
Skin Pigmentation
Human Genome
Skeleton
Spain
Genes
Breeding
Immunity
Demography
Genome
Diet
Light
Skin
Farmers

All Science Journal Classification (ASJC) codes

  • General

Cite this

Olalde, I., Allentoft, M. E., Sánchez-Quinto, F., Santpere, G., Chiang, C. W. K., DeGiorgio, M., ... Lalueza-Fox, C. (2014). Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature, 507(7491), 225-228. https://doi.org/10.1038/nature12960
Olalde, Iñigo ; Allentoft, Morten E. ; Sánchez-Quinto, Federico ; Santpere, Gabriel ; Chiang, Charleston W.K. ; DeGiorgio, Michael ; Prado-Martinez, Javier ; Rodríguez, Juan Antonio ; Rasmussen, Simon ; Quilez, Javier ; Ramírez, Oscar ; Marigorta, Urko M. ; Fernández-Callejo, Marcos ; Prada, María Encina ; Encinas, Julio Manuel Vidal ; Nielsen, Rasmus ; Netea, Mihai G. ; Novembre, John ; Sturm, Richard A. ; Sabeti, Pardis ; Marquès-Bonet, Tomàs ; Navarro, Arcadi ; Willerslev, Eske ; Lalueza-Fox, Carles. / Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. In: Nature. 2014 ; Vol. 507, No. 7491. pp. 225-228.
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abstract = "Ancient genomic sequences have started to reveal the origin and the demographic impact of farmers from the Neolithic period spreading into Europe. The adoption of farming, stock breeding and sedentary societies during the Neolithic may have resulted in adaptive changes in genes associated with immunity and diet. However, the limited data available from earlier hunter-gatherers preclude an understanding of the selective processes associated with this crucial transition to agriculture in recent human evolution. Here we sequence an approximately 7,000-year-old Mesolithic skeleton discovered at the La Bra{\~n}a-Arintero site in Le{\'o}n, Spain, to retrieve a complete pre-agricultural European human genome. Analysis of this genome in the context of other ancient samples suggests the existence of a common ancient genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic. The La Bra{\~n}a individual carries ancestral alleles in several skin pigmentation genes, suggesting that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times. Moreover, we provide evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.",
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Olalde, I, Allentoft, ME, Sánchez-Quinto, F, Santpere, G, Chiang, CWK, DeGiorgio, M, Prado-Martinez, J, Rodríguez, JA, Rasmussen, S, Quilez, J, Ramírez, O, Marigorta, UM, Fernández-Callejo, M, Prada, ME, Encinas, JMV, Nielsen, R, Netea, MG, Novembre, J, Sturm, RA, Sabeti, P, Marquès-Bonet, T, Navarro, A, Willerslev, E & Lalueza-Fox, C 2014, 'Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European', Nature, vol. 507, no. 7491, pp. 225-228. https://doi.org/10.1038/nature12960

Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. / Olalde, Iñigo; Allentoft, Morten E.; Sánchez-Quinto, Federico; Santpere, Gabriel; Chiang, Charleston W.K.; DeGiorgio, Michael; Prado-Martinez, Javier; Rodríguez, Juan Antonio; Rasmussen, Simon; Quilez, Javier; Ramírez, Oscar; Marigorta, Urko M.; Fernández-Callejo, Marcos; Prada, María Encina; Encinas, Julio Manuel Vidal; Nielsen, Rasmus; Netea, Mihai G.; Novembre, John; Sturm, Richard A.; Sabeti, Pardis; Marquès-Bonet, Tomàs; Navarro, Arcadi; Willerslev, Eske; Lalueza-Fox, Carles.

In: Nature, Vol. 507, No. 7491, 01.01.2014, p. 225-228.

Research output: Contribution to journalArticle

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AU - Marigorta, Urko M.

AU - Fernández-Callejo, Marcos

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AU - Sturm, Richard A.

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AU - Marquès-Bonet, Tomàs

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Olalde I, Allentoft ME, Sánchez-Quinto F, Santpere G, Chiang CWK, DeGiorgio M et al. Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature. 2014 Jan 1;507(7491):225-228. https://doi.org/10.1038/nature12960