Dermal mucinosis as a sign of venous insufficiency

Rupa Pugashetti, Daniel C. Zedek, Elizabeth V. Seiverling, Priya Rajendran, Timothy Berger

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Dermal mucinoses are a heterogeneous group of disorders characterized by abnormal deposition of dermal mucin, an amorphous substance composed of hyaluronic acid and sulfated glycosaminoglycans. We describe two cases of dermal mucinosis in the setting of chronic venous insufficiency. Both patients presented with painful, edematous lower extremity plaques. Biopsies of all lesions showed striking dermal mucin deposition, a slight increase in small blood vessel density, slightly thickened vessel walls and no inflammation. Neither patient showed laboratory or clinical findings consistent with a secondary mucinosis such as thyroid dysfunction, lupus erythematosus, dermatomyositis, scleroderma, granuloma annulare, graft-vs.-host disease or mucin deposition post-ultraviolet or photochemotherapy treatment. Both patients were diagnosed with localized cutaneous mucinosis secondary to venous insufficiency. The clinicopathological features of this entity are described, and a pathogenic mechanism is proposed. Pugashetti R, Zedek DC, Seiverling EV, Rajendran P. Berger T. Dermal mucinosis as a sign of venous insufficiency.

Original languageEnglish (US)
Pages (from-to)292-296
Number of pages5
JournalJournal of Cutaneous Pathology
Volume37
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Mucinoses
Venous Insufficiency
Skin
Mucins
A73025
Granuloma Annulare
Dermatomyositis
Photochemotherapy
Hyaluronic Acid
Blood Vessels
Lower Extremity
Thyroid Gland
Inflammation
Transplants
Biopsy

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

Pugashetti, R., Zedek, D. C., Seiverling, E. V., Rajendran, P., & Berger, T. (2010). Dermal mucinosis as a sign of venous insufficiency. Journal of Cutaneous Pathology, 37(2), 292-296. https://doi.org/10.1111/j.1600-0560.2009.01306.x
Pugashetti, Rupa ; Zedek, Daniel C. ; Seiverling, Elizabeth V. ; Rajendran, Priya ; Berger, Timothy. / Dermal mucinosis as a sign of venous insufficiency. In: Journal of Cutaneous Pathology. 2010 ; Vol. 37, No. 2. pp. 292-296.
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Pugashetti, R, Zedek, DC, Seiverling, EV, Rajendran, P & Berger, T 2010, 'Dermal mucinosis as a sign of venous insufficiency', Journal of Cutaneous Pathology, vol. 37, no. 2, pp. 292-296. https://doi.org/10.1111/j.1600-0560.2009.01306.x

Dermal mucinosis as a sign of venous insufficiency. / Pugashetti, Rupa; Zedek, Daniel C.; Seiverling, Elizabeth V.; Rajendran, Priya; Berger, Timothy.

In: Journal of Cutaneous Pathology, Vol. 37, No. 2, 01.02.2010, p. 292-296.

Research output: Contribution to journalArticle

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Pugashetti R, Zedek DC, Seiverling EV, Rajendran P, Berger T. Dermal mucinosis as a sign of venous insufficiency. Journal of Cutaneous Pathology. 2010 Feb 1;37(2):292-296. https://doi.org/10.1111/j.1600-0560.2009.01306.x