Abstract
Aspirin (ASA) hypersensitivity comprises types I to III (Cox-1 mediated) and types IV and V (IgE antibody mediated). Rapid, low-dose (81-325 mg/day) ASA desensitization regimens are known to be useful in establishing ASA tolerance in patients with coronary artery disease and coexisting ASA/nonsteroidal anti-inflammatory drug hypersensitivity. We document 3 cases in Vietnam of desensitization to ASA in patients with coronary artery disease and coexisting ASA hypersensitivity. One of these 3 patients had probable immune-mediated hypersensitivity, whereas the remaining 2 had probable Cox-1-mediated reactions. The regimen of desensitization we employed for each patient was designed to account for the probable mechanism of hypersensitivity in the individual and further modified according to the degree of tolerance observed, with all 3 patients eventually achieving a daily cardioprotective dosage of ASA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 170-173 |
| Number of pages | 4 |
| Journal | World Allergy Organization Journal |
| Volume | 5 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2012 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Pulmonary and Respiratory Medicine
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Description of 3 cases in Vietnam of aspirin desensitization in patients with coronary artery disease and coexisting aspirin hypersensitivity. / Van Nguyen, Dinh; Chi, Hieu Chu; Van Nguyen, Doan; Craig, Timothy J.; Van Nunen, Sheryl.
In: World Allergy Organization Journal, Vol. 5, No. 11, 11.2012, p. 170-173.Research output: Contribution to journal › Article
TY - JOUR
T1 - Description of 3 cases in Vietnam of aspirin desensitization in patients with coronary artery disease and coexisting aspirin hypersensitivity
AU - Van Nguyen, Dinh
AU - Chi, Hieu Chu
AU - Van Nguyen, Doan
AU - Craig, Timothy J.
AU - Van Nunen, Sheryl
PY - 2012/11
Y1 - 2012/11
N2 - Aspirin (ASA) hypersensitivity comprises types I to III (Cox-1 mediated) and types IV and V (IgE antibody mediated). Rapid, low-dose (81-325 mg/day) ASA desensitization regimens are known to be useful in establishing ASA tolerance in patients with coronary artery disease and coexisting ASA/nonsteroidal anti-inflammatory drug hypersensitivity. We document 3 cases in Vietnam of desensitization to ASA in patients with coronary artery disease and coexisting ASA hypersensitivity. One of these 3 patients had probable immune-mediated hypersensitivity, whereas the remaining 2 had probable Cox-1-mediated reactions. The regimen of desensitization we employed for each patient was designed to account for the probable mechanism of hypersensitivity in the individual and further modified according to the degree of tolerance observed, with all 3 patients eventually achieving a daily cardioprotective dosage of ASA.
AB - Aspirin (ASA) hypersensitivity comprises types I to III (Cox-1 mediated) and types IV and V (IgE antibody mediated). Rapid, low-dose (81-325 mg/day) ASA desensitization regimens are known to be useful in establishing ASA tolerance in patients with coronary artery disease and coexisting ASA/nonsteroidal anti-inflammatory drug hypersensitivity. We document 3 cases in Vietnam of desensitization to ASA in patients with coronary artery disease and coexisting ASA hypersensitivity. One of these 3 patients had probable immune-mediated hypersensitivity, whereas the remaining 2 had probable Cox-1-mediated reactions. The regimen of desensitization we employed for each patient was designed to account for the probable mechanism of hypersensitivity in the individual and further modified according to the degree of tolerance observed, with all 3 patients eventually achieving a daily cardioprotective dosage of ASA.
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UR - http://www.scopus.com/inward/citedby.url?scp=84872236665&partnerID=8YFLogxK
U2 - 10.1097/WOX.0b013e3182718327
DO - 10.1097/WOX.0b013e3182718327
M3 - Article
C2 - 23282385
AN - SCOPUS:84872236665
VL - 5
SP - 170
EP - 173
JO - World Allergy Organization Journal
JF - World Allergy Organization Journal
SN - 1939-4551
IS - 11
ER -