Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study

John A. Dodson, Mary Geda, Harlan M. Krumholz, Nancy Lorenze, Terrence E. Murphy, Heather G. Allore, Peter Charpentier, Sui W. Tsang, Denise Acampora, Mary E. Tinetti, Thomas M. Gill, Sarwat I. Chaudhry

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Background: While older adults (age 75 and over) represent a large and growing proportion of patients with acute myocardial infarction (AMI), they have traditionally been under-represented in cardiovascular studies. Although chronological age confers an increased risk for adverse outcomes, our current understanding of the heterogeneity of this risk is limited. The Comprehensive Evaluation of Risk Factors in Older Patients with AMI (SILVER-AMI) study was designed to address this gap in knowledge by evaluating risk factors (including geriatric impairments, such as muscle weakness and cognitive impairments) for hospital readmission, mortality, and health status decline among older adults hospitalized for AMI. Methods/Design: SILVER-AMI is a prospective cohort study that is enrolling 3000 older adults hospitalized for AMI from a recruitment network of approximately 70 community and academic hospitals across the United States. Participants undergo a comprehensive in-hospital assessment that includes clinical characteristics, geriatric impairments, and health status measures. Detailed medical record abstraction complements the assessment with diagnostic study results, in-hospital procedures, and medications. Participants are subsequently followed for six months to determine hospital readmission, mortality, and health status decline. Multivariable regression will be used to develop risk models for these three outcomes. Discussion: SILVER-AMI will fill critical gaps in our understanding of AMI in older patients. By incorporating geriatric impairments into our understanding of post-AMI outcomes, we aim to create a more personalized assessment of risk and identify potential targets for interventions.

Original languageEnglish (US)
Article number506
JournalBMC health services research
Issue number1
StatePublished - 2014

All Science Journal Classification (ASJC) codes

  • Health Policy


Dive into the research topics of 'Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study'. Together they form a unique fingerprint.

Cite this