Design and testing of ribozymes for cancer gene therapy

James S. Norris; Brian Hoel; Dale Voeks; Frideriki Maggouta; Michael Dahm; Weihua Pan; Gary Clawson

Design and testing of ribozymes for cancer gene therapy

James S. Norris, Brian Hoel, Dale Voeks, Frideriki Maggouta, Michael Dahm, Weihua Pan, Gary Clawson

Research output: Contribution to journal › Review article › peer-review

Abstract

This chapter describes procedural aspects for development of ribozymes in general, and specifically, that cleave mRNA to an essential cellular gene, the AC40 subunit of RNA pol I. Ribozyme design includes functional selection of binding sites followed by computer modeling. These ribozymes are being used in vectors that target expression to the prostate via tissue specific promoters (Voeks, Norris, and Clawson, 1998) and have demonstrated efficacy.

Original language	English (US)
Pages (from-to)	293-301
Number of pages	9
Journal	Advances in experimental medicine and biology
Volume	465
State	Published - Jan 1 2000

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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AU - Pan, Weihua

AU - Clawson, Gary

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Design and testing of ribozymes for cancer gene therapy

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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