Design and testing of ribozymes for cancer gene therapy

James S. Norris, Brian Hoel, Dale Voeks, Frideriki Maggouta, Michael Dahm, Weihua Pan, Gary Clawson

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

This chapter describes procedural aspects for development of ribozymes in general, and specifically, that cleave mRNA to an essential cellular gene, the AC40 subunit of RNA pol I. Ribozyme design includes functional selection of binding sites followed by computer modeling. These ribozymes are being used in vectors that target expression to the prostate via tissue specific promoters (Voeks, Norris, and Clawson, 1998) and have demonstrated efficacy.

Original languageEnglish (US)
Pages (from-to)293-301
Number of pages9
JournalAdvances in experimental medicine and biology
Volume465
StatePublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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