Design of a physiologic pulsatile flow cardiopulmonary bypass system for neonates and infants

Akif Undar, T. M. Runge, O. L. Miller, M. C. Felger, R. Lansing, D. L. Korvick, F. O. Bohls, S. E. Ottmers, B. J. O'Dell, J. R. Ybarra, R. V. Howelton, R. Z. Mireles, C. K. Benson, M. C. Holland, J. H. Calhoon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cardiopulmonary bypass surgical techniques that allow a surgeon to operate on the infant's heart use an extracorporeal circuit consisting of a pump, oxygenator, arterial and venous reservoirs, cannulae, an arterial filter, and tubing. The extracorporeal technique currently used in infants and neonates is sometimes associated with neurologic damage. We are developing a modified cardiopulmonary bypass system for neonates that has been tested in vitro and in one animal in vivo. Unlike other extracorporeal circuits which use steady flow, this system utilizes pulsatile flow, a low prime volume (500 ml) and a closed circuit. During in vitro experiments, the pseudo patient's mean arterial pressure was kept constant at 40 mmHg and the extracorporeal circuit pressure did not exceed a mean pressure of 200 mmHg. In our single in vivo experiment, the primary objective was to determine whether physiologic pulsatility with a 1OF (3.3 mm) aortic cannula could be achieved. The results suggest that this is possible.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
JournalInternational Journal of Artificial Organs
Volume19
Issue number3
StatePublished - Mar 15 1996

Fingerprint

Pulsatile Flow
Pulsatile flow
Cardiopulmonary Bypass
Newborn Infant
Oxygenators
Pressure
Vascular Access Devices
Networks (circuits)
Nervous System
Arterial Pressure
Steady flow
Tubing
Animals
Experiments
Pumps
Cannula
In Vitro Techniques
Surgeons

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Undar, A., Runge, T. M., Miller, O. L., Felger, M. C., Lansing, R., Korvick, D. L., ... Calhoon, J. H. (1996). Design of a physiologic pulsatile flow cardiopulmonary bypass system for neonates and infants. International Journal of Artificial Organs, 19(3), 170-176.
Undar, Akif ; Runge, T. M. ; Miller, O. L. ; Felger, M. C. ; Lansing, R. ; Korvick, D. L. ; Bohls, F. O. ; Ottmers, S. E. ; O'Dell, B. J. ; Ybarra, J. R. ; Howelton, R. V. ; Mireles, R. Z. ; Benson, C. K. ; Holland, M. C. ; Calhoon, J. H. / Design of a physiologic pulsatile flow cardiopulmonary bypass system for neonates and infants. In: International Journal of Artificial Organs. 1996 ; Vol. 19, No. 3. pp. 170-176.
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Undar, A, Runge, TM, Miller, OL, Felger, MC, Lansing, R, Korvick, DL, Bohls, FO, Ottmers, SE, O'Dell, BJ, Ybarra, JR, Howelton, RV, Mireles, RZ, Benson, CK, Holland, MC & Calhoon, JH 1996, 'Design of a physiologic pulsatile flow cardiopulmonary bypass system for neonates and infants', International Journal of Artificial Organs, vol. 19, no. 3, pp. 170-176.

Design of a physiologic pulsatile flow cardiopulmonary bypass system for neonates and infants. / Undar, Akif; Runge, T. M.; Miller, O. L.; Felger, M. C.; Lansing, R.; Korvick, D. L.; Bohls, F. O.; Ottmers, S. E.; O'Dell, B. J.; Ybarra, J. R.; Howelton, R. V.; Mireles, R. Z.; Benson, C. K.; Holland, M. C.; Calhoon, J. H.

In: International Journal of Artificial Organs, Vol. 19, No. 3, 15.03.1996, p. 170-176.

Research output: Contribution to journalArticle

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AU - Undar, Akif

AU - Runge, T. M.

AU - Miller, O. L.

AU - Felger, M. C.

AU - Lansing, R.

AU - Korvick, D. L.

AU - Bohls, F. O.

AU - Ottmers, S. E.

AU - O'Dell, B. J.

AU - Ybarra, J. R.

AU - Howelton, R. V.

AU - Mireles, R. Z.

AU - Benson, C. K.

AU - Holland, M. C.

AU - Calhoon, J. H.

PY - 1996/3/15

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