Detection and characterization of 1,2-dibromoethane-derived dna crosslinks formed with O6-alkylguanine-DNA alkyltransferase

Goutam Chowdhury, Sung Hee Cho, Anthony Pegg, F. Peter Guengerich

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A combination of chemical modifications and LC-tandem MS was used for the structure elucidation of various ethylene crosslinks of DNA with O 6-alkylguanine-DNA alkyltransferase (AGT, see picture). The elucidation of the chemical structures of such DNA-protein crosslinks is necessary to understand mechanisms of mutagenesis.

Original languageEnglish (US)
Pages (from-to)12879-12882
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number49
DOIs
StatePublished - Dec 2 2013

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Detection and characterization of 1,2-dibromoethane-derived dna crosslinks formed with O<sup>6</sup>-alkylguanine-DNA alkyltransferase'. Together they form a unique fingerprint.

Cite this