Detection and characterization of 1,2-dibromoethane-derived dna crosslinks formed with O6-alkylguanine-DNA alkyltransferase

Goutam Chowdhury, Sung Hee Cho, Anthony Pegg, F. Peter Guengerich

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A combination of chemical modifications and LC-tandem MS was used for the structure elucidation of various ethylene crosslinks of DNA with O 6-alkylguanine-DNA alkyltransferase (AGT, see picture). The elucidation of the chemical structures of such DNA-protein crosslinks is necessary to understand mechanisms of mutagenesis.

Original languageEnglish (US)
Pages (from-to)12879-12882
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number49
DOIs
StatePublished - Dec 2 2013

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Ethylene Dibromide
DNA
O(6)-Methylguanine-DNA Methyltransferase
Mutagenesis
Chemical modification
Ethylene
Proteins
DNA alkyltransferase

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

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Detection and characterization of 1,2-dibromoethane-derived dna crosslinks formed with O6-alkylguanine-DNA alkyltransferase. / Chowdhury, Goutam; Cho, Sung Hee; Pegg, Anthony; Guengerich, F. Peter.

In: Angewandte Chemie - International Edition, Vol. 52, No. 49, 02.12.2013, p. 12879-12882.

Research output: Contribution to journalArticle

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