Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam

Dung Van Nguyen, Cuong Van Nguyen, David Bonsall, Tue Tri Ngo, Juan Carrique-Mas, Anh Hong Pham, Juliet E. Bryant, Guy Thwaites, Stephen Baker, Mark Woolhouse, Peter Simmonds, Bach Tuan Kiet, Alessandra Berto, Maciej F. Boni, Juliet E. Bryant, Bui Duc Phu, James I. Campbell, Dang Manh Hung, Dang Thao Huong, Dang Tram OanhJeremy N. Day, Dinh Van Tan, H. Rogier van Doorn, Duong An Han, Jeremy J. Farrar, Hau Thi Thu Trang, Ho Dang Trung Nghia, Hoang Bao Long, Hoang Van Duong, Huynh Thi Kim Thu, Lam Chi Cuong, Le Manh Hung, Le Thanh Phuong, Le Thi Phuc, Le Thi Phuong, Le Xuan Luat, Luu Thi Thu Ha, Ly Van Chuong, Mai Thi Phuoc Loan, Behzad Nadjm, Ngo Thanh Bao, Ngo Thi Hoa, Ngo Tri Tue, Nguyen Canh Tu, Nguyen Dac Thuan, Nguyen Dong, Nguyen Khac Chuyen, Nguyen Ngoc An, Nguyen Ngoc Vinh, Nguyen Quoc Hung, Nguyen Thanh Dung, Nguyen Thanh Minh, Nguyen Thi Binh, Nguyen Thi Hong Tham, Nguyen Thi Hong Tien, Nguyen Thi Kim Chuc, Nguyen Thi Le Ngoc, Nguyen Thi Lien Ha, Nguyen Thi Nam Lien, Nguyen Thi Ngoc Diep, Nguyen Thi Nhung, Nguyen Thi Song Chau, Nguyen Thi Yen Chi, Nguyen Thieu Trinh, Nguyen Thu Van, Nguyen Van Cuong, Nguyen Van Hung, Nguyen Van Kinh, Nguyen Van Minh Hoang, Nguyen Van My, Nguyen Van Thang, Nguyen Van Thanh, Nguyen Van Vinh Chau, Nguyen Van Xang, Pham Ha My, Pham Hong Anh, Pham Thi Minh Khoa, Pham Thi Thanh Tam, Pham Van Lao, Pham Van Minh, Phan Van Be Bay, Maia A. Rabaa, Motiur Rahman, Corinne Thompson, Ta Thi Dieu Ngan, Tran Do Hoang Nhu, Tran Hoang Minh Chau, Tran Khanh Toan, Tran My Phuc, Tran Thi Kim Hong, Tran Thi Ngoc Dung, Tran Thi Thanh Thanh, Tran Thi Thuy Minh, Tran Thua Nguyen, Tran Tinh Hien, Trinh Quang Tri, Vo Be Hien, Vo Nhut Tai, Vo Quoc Cuong, Voong Vinh Phat, Vu Thi Lan Huong, Vu Thi Ty Hang, Heiman Wertheim, Carlijn Bogaardt, Liam Brierley, Margo Chase-Topping, Al Ivens, Lu Lu, Dung Nguyen, Andrew Rambaut, Matthew Cotten, Bas B.Oude Munnink, Paul Kellam, My Vu Tra Phan, Lia van der Hoek, Martin Deijs, Maarten F. Jebbink, Seyed Mohammad Jazaeri Farsani, Karen Saylors, Nathan Wolfe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.

Original languageEnglish (US)
Article number102
JournalViruses
Volume10
Issue number3
DOIs
StatePublished - Mar 1 2018

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Hepatitis Viruses
Vietnam
Rodentia
Viruses
Hepacivirus
Zoonoses
Host Specificity
Liver
Virus Diseases
Hepatitis C
Hepatitis B
Serum
Nucleic Acids
Mammals
Genome
RNA
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Virology

Cite this

Van Nguyen, D., Van Nguyen, C., Bonsall, D., Ngo, T. T., Carrique-Mas, J., Pham, A. H., ... Wolfe, N. (2018). Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam. Viruses, 10(3), [102]. https://doi.org/10.3390/v10030102
Van Nguyen, Dung ; Van Nguyen, Cuong ; Bonsall, David ; Ngo, Tue Tri ; Carrique-Mas, Juan ; Pham, Anh Hong ; Bryant, Juliet E. ; Thwaites, Guy ; Baker, Stephen ; Woolhouse, Mark ; Simmonds, Peter ; Kiet, Bach Tuan ; Berto, Alessandra ; Boni, Maciej F. ; Bryant, Juliet E. ; Phu, Bui Duc ; Campbell, James I. ; Hung, Dang Manh ; Huong, Dang Thao ; Oanh, Dang Tram ; Day, Jeremy N. ; Tan, Dinh Van ; van Doorn, H. Rogier ; Han, Duong An ; Farrar, Jeremy J. ; Trang, Hau Thi Thu ; Nghia, Ho Dang Trung ; Long, Hoang Bao ; Duong, Hoang Van ; Thu, Huynh Thi Kim ; Cuong, Lam Chi ; Hung, Le Manh ; Phuong, Le Thanh ; Phuc, Le Thi ; Phuong, Le Thi ; Luat, Le Xuan ; Ha, Luu Thi Thu ; Chuong, Ly Van ; Loan, Mai Thi Phuoc ; Nadjm, Behzad ; Bao, Ngo Thanh ; Hoa, Ngo Thi ; Tue, Ngo Tri ; Tu, Nguyen Canh ; Thuan, Nguyen Dac ; Dong, Nguyen ; Chuyen, Nguyen Khac ; An, Nguyen Ngoc ; Vinh, Nguyen Ngoc ; Hung, Nguyen Quoc ; Dung, Nguyen Thanh ; Minh, Nguyen Thanh ; Binh, Nguyen Thi ; Tham, Nguyen Thi Hong ; Tien, Nguyen Thi Hong ; Chuc, Nguyen Thi Kim ; Ngoc, Nguyen Thi Le ; Ha, Nguyen Thi Lien ; Lien, Nguyen Thi Nam ; Diep, Nguyen Thi Ngoc ; Nhung, Nguyen Thi ; Chau, Nguyen Thi Song ; Chi, Nguyen Thi Yen ; Trinh, Nguyen Thieu ; Van, Nguyen Thu ; Cuong, Nguyen Van ; Hung, Nguyen Van ; Kinh, Nguyen Van ; Hoang, Nguyen Van Minh ; My, Nguyen Van ; Thang, Nguyen Van ; Thanh, Nguyen Van ; Chau, Nguyen Van Vinh ; Xang, Nguyen Van ; My, Pham Ha ; Anh, Pham Hong ; Khoa, Pham Thi Minh ; Tam, Pham Thi Thanh ; Lao, Pham Van ; Minh, Pham Van ; Bay, Phan Van Be ; Rabaa, Maia A. ; Rahman, Motiur ; Thompson, Corinne ; Ngan, Ta Thi Dieu ; Nhu, Tran Do Hoang ; Chau, Tran Hoang Minh ; Toan, Tran Khanh ; Phuc, Tran My ; Hong, Tran Thi Kim ; Dung, Tran Thi Ngoc ; Thanh, Tran Thi Thanh ; Minh, Tran Thi Thuy ; Nguyen, Tran Thua ; Hien, Tran Tinh ; Tri, Trinh Quang ; Hien, Vo Be ; Tai, Vo Nhut ; Cuong, Vo Quoc ; Phat, Voong Vinh ; Huong, Vu Thi Lan ; Hang, Vu Thi Ty ; Wertheim, Heiman ; Bogaardt, Carlijn ; Brierley, Liam ; Chase-Topping, Margo ; Ivens, Al ; Lu, Lu ; Nguyen, Dung ; Rambaut, Andrew ; Cotten, Matthew ; Munnink, Bas B.Oude ; Kellam, Paul ; Phan, My Vu Tra ; van der Hoek, Lia ; Deijs, Martin ; Jebbink, Maarten F. ; Farsani, Seyed Mohammad Jazaeri ; Saylors, Karen ; Wolfe, Nathan. / Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam. In: Viruses. 2018 ; Vol. 10, No. 3.
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Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam. / Van Nguyen, Dung; Van Nguyen, Cuong; Bonsall, David; Ngo, Tue Tri; Carrique-Mas, Juan; Pham, Anh Hong; Bryant, Juliet E.; Thwaites, Guy; Baker, Stephen; Woolhouse, Mark; Simmonds, Peter; Kiet, Bach Tuan; Berto, Alessandra; Boni, Maciej F.; Bryant, Juliet E.; Phu, Bui Duc; Campbell, James I.; Hung, Dang Manh; Huong, Dang Thao; Oanh, Dang Tram; Day, Jeremy N.; Tan, Dinh Van; van Doorn, H. Rogier; Han, Duong An; Farrar, Jeremy J.; Trang, Hau Thi Thu; Nghia, Ho Dang Trung; Long, Hoang Bao; Duong, Hoang Van; Thu, Huynh Thi Kim; Cuong, Lam Chi; Hung, Le Manh; Phuong, Le Thanh; Phuc, Le Thi; Phuong, Le Thi; Luat, Le Xuan; Ha, Luu Thi Thu; Chuong, Ly Van; Loan, Mai Thi Phuoc; Nadjm, Behzad; Bao, Ngo Thanh; Hoa, Ngo Thi; Tue, Ngo Tri; Tu, Nguyen Canh; Thuan, Nguyen Dac; Dong, Nguyen; Chuyen, Nguyen Khac; An, Nguyen Ngoc; Vinh, Nguyen Ngoc; Hung, Nguyen Quoc; Dung, Nguyen Thanh; Minh, Nguyen Thanh; Binh, Nguyen Thi; Tham, Nguyen Thi Hong; Tien, Nguyen Thi Hong; Chuc, Nguyen Thi Kim; Ngoc, Nguyen Thi Le; Ha, Nguyen Thi Lien; Lien, Nguyen Thi Nam; Diep, Nguyen Thi Ngoc; Nhung, Nguyen Thi; Chau, Nguyen Thi Song; Chi, Nguyen Thi Yen; Trinh, Nguyen Thieu; Van, Nguyen Thu; Cuong, Nguyen Van; Hung, Nguyen Van; Kinh, Nguyen Van; Hoang, Nguyen Van Minh; My, Nguyen Van; Thang, Nguyen Van; Thanh, Nguyen Van; Chau, Nguyen Van Vinh; Xang, Nguyen Van; My, Pham Ha; Anh, Pham Hong; Khoa, Pham Thi Minh; Tam, Pham Thi Thanh; Lao, Pham Van; Minh, Pham Van; Bay, Phan Van Be; Rabaa, Maia A.; Rahman, Motiur; Thompson, Corinne; Ngan, Ta Thi Dieu; Nhu, Tran Do Hoang; Chau, Tran Hoang Minh; Toan, Tran Khanh; Phuc, Tran My; Hong, Tran Thi Kim; Dung, Tran Thi Ngoc; Thanh, Tran Thi Thanh; Minh, Tran Thi Thuy; Nguyen, Tran Thua; Hien, Tran Tinh; Tri, Trinh Quang; Hien, Vo Be; Tai, Vo Nhut; Cuong, Vo Quoc; Phat, Voong Vinh; Huong, Vu Thi Lan; Hang, Vu Thi Ty; Wertheim, Heiman; Bogaardt, Carlijn; Brierley, Liam; Chase-Topping, Margo; Ivens, Al; Lu, Lu; Nguyen, Dung; Rambaut, Andrew; Cotten, Matthew; Munnink, Bas B.Oude; Kellam, Paul; Phan, My Vu Tra; van der Hoek, Lia; Deijs, Martin; Jebbink, Maarten F.; Farsani, Seyed Mohammad Jazaeri; Saylors, Karen; Wolfe, Nathan.

In: Viruses, Vol. 10, No. 3, 102, 01.03.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam

AU - Van Nguyen, Dung

AU - Van Nguyen, Cuong

AU - Bonsall, David

AU - Ngo, Tue Tri

AU - Carrique-Mas, Juan

AU - Pham, Anh Hong

AU - Bryant, Juliet E.

AU - Thwaites, Guy

AU - Baker, Stephen

AU - Woolhouse, Mark

AU - Simmonds, Peter

AU - Kiet, Bach Tuan

AU - Berto, Alessandra

AU - Boni, Maciej F.

AU - Bryant, Juliet E.

AU - Phu, Bui Duc

AU - Campbell, James I.

AU - Hung, Dang Manh

AU - Huong, Dang Thao

AU - Oanh, Dang Tram

AU - Day, Jeremy N.

AU - Tan, Dinh Van

AU - van Doorn, H. Rogier

AU - Han, Duong An

AU - Farrar, Jeremy J.

AU - Trang, Hau Thi Thu

AU - Nghia, Ho Dang Trung

AU - Long, Hoang Bao

AU - Duong, Hoang Van

AU - Thu, Huynh Thi Kim

AU - Cuong, Lam Chi

AU - Hung, Le Manh

AU - Phuong, Le Thanh

AU - Phuc, Le Thi

AU - Phuong, Le Thi

AU - Luat, Le Xuan

AU - Ha, Luu Thi Thu

AU - Chuong, Ly Van

AU - Loan, Mai Thi Phuoc

AU - Nadjm, Behzad

AU - Bao, Ngo Thanh

AU - Hoa, Ngo Thi

AU - Tue, Ngo Tri

AU - Tu, Nguyen Canh

AU - Thuan, Nguyen Dac

AU - Dong, Nguyen

AU - Chuyen, Nguyen Khac

AU - An, Nguyen Ngoc

AU - Vinh, Nguyen Ngoc

AU - Hung, Nguyen Quoc

AU - Dung, Nguyen Thanh

AU - Minh, Nguyen Thanh

AU - Binh, Nguyen Thi

AU - Tham, Nguyen Thi Hong

AU - Tien, Nguyen Thi Hong

AU - Chuc, Nguyen Thi Kim

AU - Ngoc, Nguyen Thi Le

AU - Ha, Nguyen Thi Lien

AU - Lien, Nguyen Thi Nam

AU - Diep, Nguyen Thi Ngoc

AU - Nhung, Nguyen Thi

AU - Chau, Nguyen Thi Song

AU - Chi, Nguyen Thi Yen

AU - Trinh, Nguyen Thieu

AU - Van, Nguyen Thu

AU - Cuong, Nguyen Van

AU - Hung, Nguyen Van

AU - Kinh, Nguyen Van

AU - Hoang, Nguyen Van Minh

AU - My, Nguyen Van

AU - Thang, Nguyen Van

AU - Thanh, Nguyen Van

AU - Chau, Nguyen Van Vinh

AU - Xang, Nguyen Van

AU - My, Pham Ha

AU - Anh, Pham Hong

AU - Khoa, Pham Thi Minh

AU - Tam, Pham Thi Thanh

AU - Lao, Pham Van

AU - Minh, Pham Van

AU - Bay, Phan Van Be

AU - Rabaa, Maia A.

AU - Rahman, Motiur

AU - Thompson, Corinne

AU - Ngan, Ta Thi Dieu

AU - Nhu, Tran Do Hoang

AU - Chau, Tran Hoang Minh

AU - Toan, Tran Khanh

AU - Phuc, Tran My

AU - Hong, Tran Thi Kim

AU - Dung, Tran Thi Ngoc

AU - Thanh, Tran Thi Thanh

AU - Minh, Tran Thi Thuy

AU - Nguyen, Tran Thua

AU - Hien, Tran Tinh

AU - Tri, Trinh Quang

AU - Hien, Vo Be

AU - Tai, Vo Nhut

AU - Cuong, Vo Quoc

AU - Phat, Voong Vinh

AU - Huong, Vu Thi Lan

AU - Hang, Vu Thi Ty

AU - Wertheim, Heiman

AU - Bogaardt, Carlijn

AU - Brierley, Liam

AU - Chase-Topping, Margo

AU - Ivens, Al

AU - Lu, Lu

AU - Nguyen, Dung

AU - Rambaut, Andrew

AU - Cotten, Matthew

AU - Munnink, Bas B.Oude

AU - Kellam, Paul

AU - Phan, My Vu Tra

AU - van der Hoek, Lia

AU - Deijs, Martin

AU - Jebbink, Maarten F.

AU - Farsani, Seyed Mohammad Jazaeri

AU - Saylors, Karen

AU - Wolfe, Nathan

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.

AB - Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.

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