Detection of Leukemia-Related Karyotypes in Granulocyte/Macrophage Colonies from a Patient with Acute Myelomonocytic Leukemia

Michael M. Reid, Ramana Tantravahi, Holcombe E. Grier, Susan O'toole, Barbara A. Miller, Jeffrey M. Lipton, Howard J. Weinstein, David G. Nathan

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The use of chromosome-banding techniques to identify metaphase chromosomes in hematopoietic colonies derived from marrow cultures from patients with acute nonlymphocytic leukemia (ANLL) offers an opportunity to study the extent of involvement of progenitor cells in the leukemic process. Several lines of evidence have demonstrated that chronic myelogenous leukemia is a clonal hematopoietic stem-cell disorder.1 The Philadelphia chromosome, detectable in 90 per cent of patients with chronic myelogenous leukemia, has been found in colonies grown from committed granulocyte and erythroid progenitors in vitro.2,3 Other studies have used female patients who were heterozygous for the X-chromosome-linked enzyme glucose-6-phosphate dehydrogenase. Both forms.

Original languageEnglish (US)
Pages (from-to)1324-1328
Number of pages5
JournalNew England Journal of Medicine
Volume308
Issue number22
DOIs
Publication statusPublished - Jun 2 1983

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this