Determinants of decline in resting metabolic rate in aging females

E. T. Poehlman, M. I. Goran, A. W. Gardner, P. A. Ades, P. J. Arciero, S. M. Katzman- Rooks, S. M. Montgomery, M. J. Toth, P. T. Sutherland

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Abstract

We considered the association of several metabolic and lifestyle variables as modulators of the decline in resting metabolic rate (RMR) and fat-free weight (FFW) in 183 healthy females (18-81 yr); RMR showed a curvilinear decline with age, which was significant in women aged 51-81 yr but not in women aged 18-50 yr. FFW showed a curvilinear decline with age, which was significant (P < 0.01) in women 48-81 yr but not in women 18-47 yr. The decline in RMR was primarily associated with the loss of FFW (r2 = 72%), whereas the decline in FFW was explained primarily by differences in maximal O2 consumption (V̇O(2 max)), age, leisure time physical activity, and dietary protein intake (total r2 = 46%). We conclude that RMR and FFW showed a curvilinear decline with age which was accelerated beyond the middle-age years. Second, the age-related decline in RMR was primarily associated with the loss of FFW. Third, the loss of FFW was partially related to a decrement in V̇(2 max) and nutritional factors. Therapeutic interventions designed to increase V̇O(2 max) by elevating physical activity may preserve fat-free weight and thus offset the decline of RMR in aging women.

Original languageEnglish (US)
Pages (from-to)E450-E455
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume264
Issue number3 27-3
DOIs
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

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    Poehlman, E. T., Goran, M. I., Gardner, A. W., Ades, P. A., Arciero, P. J., Katzman- Rooks, S. M., Montgomery, S. M., Toth, M. J., & Sutherland, P. T. (1993). Determinants of decline in resting metabolic rate in aging females. American Journal of Physiology - Endocrinology and Metabolism, 264(3 27-3), E450-E455. https://doi.org/10.1152/ajpendo.1993.264.3.e450