Determinants of ligand affinity and heme reactivity in H-NOX domains

Emily E. Weinert, Lars Plate, Charlotte A. Whited, Charles Olea, Michael A. Marletta

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Figure Presented O2 balks at extra bulk: The introduction of distal-pocket bulk into the Thermoanaerobacter tengcongensis H-NOX (heme nitric oxide/oxygen) domain caused key changes in the protein structure. Rearrangement of the heme pocket resulted in dramatic differences in O2-binding kinetics and heme reactivity (see picture).

Original languageEnglish (US)
Pages (from-to)720-723
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number4
DOIs
StatePublished - Jan 18 2010

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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