Determinants of peak Vo2 in peripheral arterial occlusive disease patients

Alice S. Ryan, Leslie I. Katzel, Andrew W. Gardner

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Peripheral arterial occlusive disease (PAOD) patients with intermittent claudication are functionally limited and deconditioned. This study examined whether peak aerobic capacity (Vo2 peak) was associated with PAOD severity, muscle mass, and comorbidities in 109 PAOD patients (93 men and 16 women) aged 48-86 years. The Vo2 peak (1.12 ± 0.34 L/min), percentage body fat (30.6 ± 8.3%), lean tissue mass of the total body (51.4 ± 8.4 kg), lean tissue mass of the legs (16.6 ± 3.0 kg), and appendicular skeletal mass (22.8 ± 4.2 kg) were determined. The lean tissue mass of the total body (r = .44), lean tissue of the legs (r = .43) and resting ankle/brachial systolic pressure index (ABI; r = .41) correlated with peak Vo2 (all p < .001). None of the comorbidity variables (obesity, arthritis, coronary artery disease, hypertension, diabetes, and smoking history) were significantly associated with peak Vo2 except smoking status. The final model for the prediction of peak Vo2 included lean tissue mass of the legs, resting ABI, smoking status, and ABI X smoking status (r2 = .37,p < .001). In older patients with intermittent claudication, lean tissue mass is an important determinant of physical performance independent of PAOD severity and smoking status. Prevention of muscle atrophy may preserve ambulatory function and peak exercise capacity in older PAOD patients.

Original languageEnglish (US)
Pages (from-to)B302-B306
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume55
Issue number6
DOIs
StatePublished - Jun 2000

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Arterial Occlusive Diseases
Peripheral Arterial Disease
Smoking
Leg
Intermittent Claudication
Comorbidity
Muscular Atrophy
Ankle
Arthritis
Adipose Tissue
Coronary Artery Disease
Arm
Obesity
History
Exercise
Blood Pressure
Hypertension
Muscles

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

Cite this

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abstract = "Peripheral arterial occlusive disease (PAOD) patients with intermittent claudication are functionally limited and deconditioned. This study examined whether peak aerobic capacity (Vo2 peak) was associated with PAOD severity, muscle mass, and comorbidities in 109 PAOD patients (93 men and 16 women) aged 48-86 years. The Vo2 peak (1.12 ± 0.34 L/min), percentage body fat (30.6 ± 8.3{\%}), lean tissue mass of the total body (51.4 ± 8.4 kg), lean tissue mass of the legs (16.6 ± 3.0 kg), and appendicular skeletal mass (22.8 ± 4.2 kg) were determined. The lean tissue mass of the total body (r = .44), lean tissue of the legs (r = .43) and resting ankle/brachial systolic pressure index (ABI; r = .41) correlated with peak Vo2 (all p < .001). None of the comorbidity variables (obesity, arthritis, coronary artery disease, hypertension, diabetes, and smoking history) were significantly associated with peak Vo2 except smoking status. The final model for the prediction of peak Vo2 included lean tissue mass of the legs, resting ABI, smoking status, and ABI X smoking status (r2 = .37,p < .001). In older patients with intermittent claudication, lean tissue mass is an important determinant of physical performance independent of PAOD severity and smoking status. Prevention of muscle atrophy may preserve ambulatory function and peak exercise capacity in older PAOD patients.",
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Determinants of peak Vo2 in peripheral arterial occlusive disease patients. / Ryan, Alice S.; Katzel, Leslie I.; Gardner, Andrew W.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 55, No. 6, 06.2000, p. B302-B306.

Research output: Contribution to journalArticle

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