Determinants of prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in an urban population

Julie B. Herbstman, Andreas Sjödin, Benjamin J. Apelberg, Frank R. Witter, Donald George Jr Patterson, Rolf U. Halden, Richard S. Jones, Annie Park, Yalin Zhang, Jochen Heidler, Larry L. Needham, Lynn R. Goldman

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Abstract

Background: Recent studies have reported blood levels of polybrominated diphenyl ethers (PBDEs) in the U.S. population. Information about neonatal levels and about the relationship to polychlorinated biphenyls (PCBs) exposures is limited. Objectives: The objective was to characterize levels and determinants of fetal exposure to PBDEs and PCBs among newborns from Baltimore, Maryland. Methods: We analyzed umbilical cord blood for eight PBDEs and 35 PCBs from infants delivered at the Johns Hopkins Hospital. Maternal and infant characteristics were abstracted from medical records. Results: Ninety-four percent of cord serum samples had quantifiable levels of at least one PBDE congener, and > 99% had at least one detectable PCB congener. PBDE concentrations in cord blood were similar to those reported in other studies from North America. Strong correlations were observed within but not across PCB and PBDE classes. Multivariate models showed that many factors independently predicted exposure to BDE-47, BDE-100, and BDE-153 and CB-118, CB-138/158, CB-153, and CB-180. Generally, infants of Asian mothers had lower PBDE and PCB levels, and infants of smokers had higher levels. Increased maternal body mass index was associated with lower levels of PCBs but not PBDEs. Levels of PCBs but not PBDEs were lower in births from married and multiparous mothers. Increased maternal age was associated with higher PCB levels but lower PBDE levels. Conclusion: Although many of the factors we investigated were independent predictors of both PBDE and PCB levels, in some cases the direction of associations was different. More research is needed to better understand the sources and pathways of PBDE exposure.

Original languageEnglish (US)
Pages (from-to)1794-1800
Number of pages7
JournalEnvironmental health perspectives
Volume115
Issue number12
DOIs
StatePublished - Dec 1 2007

Fingerprint

Halogenated Diphenyl Ethers
Urban Population
Polychlorinated Biphenyls
Mothers
2,4,5,2',4',5'-hexachlorobiphenyl
Fetal Blood
polychlorinated diphenyl ethers
Baltimore
Maternal Age
North America
Medical Records

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Herbstman, J. B., Sjödin, A., Apelberg, B. J., Witter, F. R., Patterson, D. G. J., Halden, R. U., ... Goldman, L. R. (2007). Determinants of prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in an urban population. Environmental health perspectives, 115(12), 1794-1800. https://doi.org/10.1289/ehp.10333
Herbstman, Julie B. ; Sjödin, Andreas ; Apelberg, Benjamin J. ; Witter, Frank R. ; Patterson, Donald George Jr ; Halden, Rolf U. ; Jones, Richard S. ; Park, Annie ; Zhang, Yalin ; Heidler, Jochen ; Needham, Larry L. ; Goldman, Lynn R. / Determinants of prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in an urban population. In: Environmental health perspectives. 2007 ; Vol. 115, No. 12. pp. 1794-1800.
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abstract = "Background: Recent studies have reported blood levels of polybrominated diphenyl ethers (PBDEs) in the U.S. population. Information about neonatal levels and about the relationship to polychlorinated biphenyls (PCBs) exposures is limited. Objectives: The objective was to characterize levels and determinants of fetal exposure to PBDEs and PCBs among newborns from Baltimore, Maryland. Methods: We analyzed umbilical cord blood for eight PBDEs and 35 PCBs from infants delivered at the Johns Hopkins Hospital. Maternal and infant characteristics were abstracted from medical records. Results: Ninety-four percent of cord serum samples had quantifiable levels of at least one PBDE congener, and > 99{\%} had at least one detectable PCB congener. PBDE concentrations in cord blood were similar to those reported in other studies from North America. Strong correlations were observed within but not across PCB and PBDE classes. Multivariate models showed that many factors independently predicted exposure to BDE-47, BDE-100, and BDE-153 and CB-118, CB-138/158, CB-153, and CB-180. Generally, infants of Asian mothers had lower PBDE and PCB levels, and infants of smokers had higher levels. Increased maternal body mass index was associated with lower levels of PCBs but not PBDEs. Levels of PCBs but not PBDEs were lower in births from married and multiparous mothers. Increased maternal age was associated with higher PCB levels but lower PBDE levels. Conclusion: Although many of the factors we investigated were independent predictors of both PBDE and PCB levels, in some cases the direction of associations was different. More research is needed to better understand the sources and pathways of PBDE exposure.",
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Herbstman, JB, Sjödin, A, Apelberg, BJ, Witter, FR, Patterson, DGJ, Halden, RU, Jones, RS, Park, A, Zhang, Y, Heidler, J, Needham, LL & Goldman, LR 2007, 'Determinants of prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in an urban population', Environmental health perspectives, vol. 115, no. 12, pp. 1794-1800. https://doi.org/10.1289/ehp.10333

Determinants of prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in an urban population. / Herbstman, Julie B.; Sjödin, Andreas; Apelberg, Benjamin J.; Witter, Frank R.; Patterson, Donald George Jr; Halden, Rolf U.; Jones, Richard S.; Park, Annie; Zhang, Yalin; Heidler, Jochen; Needham, Larry L.; Goldman, Lynn R.

In: Environmental health perspectives, Vol. 115, No. 12, 01.12.2007, p. 1794-1800.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Determinants of prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in an urban population

AU - Herbstman, Julie B.

AU - Sjödin, Andreas

AU - Apelberg, Benjamin J.

AU - Witter, Frank R.

AU - Patterson, Donald George Jr

AU - Halden, Rolf U.

AU - Jones, Richard S.

AU - Park, Annie

AU - Zhang, Yalin

AU - Heidler, Jochen

AU - Needham, Larry L.

AU - Goldman, Lynn R.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Background: Recent studies have reported blood levels of polybrominated diphenyl ethers (PBDEs) in the U.S. population. Information about neonatal levels and about the relationship to polychlorinated biphenyls (PCBs) exposures is limited. Objectives: The objective was to characterize levels and determinants of fetal exposure to PBDEs and PCBs among newborns from Baltimore, Maryland. Methods: We analyzed umbilical cord blood for eight PBDEs and 35 PCBs from infants delivered at the Johns Hopkins Hospital. Maternal and infant characteristics were abstracted from medical records. Results: Ninety-four percent of cord serum samples had quantifiable levels of at least one PBDE congener, and > 99% had at least one detectable PCB congener. PBDE concentrations in cord blood were similar to those reported in other studies from North America. Strong correlations were observed within but not across PCB and PBDE classes. Multivariate models showed that many factors independently predicted exposure to BDE-47, BDE-100, and BDE-153 and CB-118, CB-138/158, CB-153, and CB-180. Generally, infants of Asian mothers had lower PBDE and PCB levels, and infants of smokers had higher levels. Increased maternal body mass index was associated with lower levels of PCBs but not PBDEs. Levels of PCBs but not PBDEs were lower in births from married and multiparous mothers. Increased maternal age was associated with higher PCB levels but lower PBDE levels. Conclusion: Although many of the factors we investigated were independent predictors of both PBDE and PCB levels, in some cases the direction of associations was different. More research is needed to better understand the sources and pathways of PBDE exposure.

AB - Background: Recent studies have reported blood levels of polybrominated diphenyl ethers (PBDEs) in the U.S. population. Information about neonatal levels and about the relationship to polychlorinated biphenyls (PCBs) exposures is limited. Objectives: The objective was to characterize levels and determinants of fetal exposure to PBDEs and PCBs among newborns from Baltimore, Maryland. Methods: We analyzed umbilical cord blood for eight PBDEs and 35 PCBs from infants delivered at the Johns Hopkins Hospital. Maternal and infant characteristics were abstracted from medical records. Results: Ninety-four percent of cord serum samples had quantifiable levels of at least one PBDE congener, and > 99% had at least one detectable PCB congener. PBDE concentrations in cord blood were similar to those reported in other studies from North America. Strong correlations were observed within but not across PCB and PBDE classes. Multivariate models showed that many factors independently predicted exposure to BDE-47, BDE-100, and BDE-153 and CB-118, CB-138/158, CB-153, and CB-180. Generally, infants of Asian mothers had lower PBDE and PCB levels, and infants of smokers had higher levels. Increased maternal body mass index was associated with lower levels of PCBs but not PBDEs. Levels of PCBs but not PBDEs were lower in births from married and multiparous mothers. Increased maternal age was associated with higher PCB levels but lower PBDE levels. Conclusion: Although many of the factors we investigated were independent predictors of both PBDE and PCB levels, in some cases the direction of associations was different. More research is needed to better understand the sources and pathways of PBDE exposure.

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