Determinants of Repeat Curative Intent Surgery in Colorectal Liver Metastasis

Afif N. Kulaylat, Neil H. Bhayani, Audrey L. Stokes, Jane R. Schubart, Joyce Wong, Eric T. Kimchi, Kevin F. Staveley-O’Carroll, Jussuf T. Kaifi, Niraj J. Gusani

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Introduction: Following curative intent surgery (CIS) for colorectal liver metastasis (CRLM), repeat CIS for recurrence improves survival. The factors associated with repeat CIS are not widely reported. Methods: An institutional database (January 2002–December 2012) was reviewed to evaluate factors influencing repeat CIS. Results: One hundred sixty-three patients with colorectal liver metastasis (CRLM) underwent successful CIS. Median follow-up and disease-free interval (DFI) was 33 and 16 months, respectively. After initial CIS, 102 patients (63 %) recurred. Fifty-three patients (52 %) underwent a repeat CIS. After repeat CIS, 33 patients (62 %) developed a second recurrence, and in 13 patients (39 %), a third CIS was possible. DFI decreased following initial CIS (first CIS vs. second CIS vs. third CIS [20 vs. 15 vs. 8.5 months], p < 0.001). Overall 5-year survival in all patients was 55 %; patients who recurred had a 5-year survival of 67 % if they underwent repeat CIS vs. 7.8 % if they were managed palliatively. Second CIS was less likely with a postoperative complication, other/multifocal recurrence, or DFI <12 months. Conclusion: Despite high recurrence and decreasing DFI, repeat CIS provides a survival benefit. Postoperative complications, DFI, number, and pattern of recurrence influence the decision to pursue repeat CIS.

Original languageEnglish (US)
Pages (from-to)1894-1901
Number of pages8
JournalJournal of Gastrointestinal Surgery
Volume18
Issue number11
DOIs
StatePublished - Nov 2014

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology

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