Determinstic lateral displacement MEMS device for continuous blood cell separation

Siyang Zheng, Raylene Yung, Yu Chong Tai, Harvey Kasdan

Research output: Contribution to journalConference articlepeer-review

43 Scopus citations

Abstract

This work presents a new MEMS device which uses deterministic lateral displacement for the continuous separation of leukocytes (white blood cells) and erythrocytes (red blood cells). By running blood cells in laminar flow through an array of columnar obstacles, deterministic lateral displacement asserts that the path a cell follows is determined by its size. The system consists of PDMS channels with posts on glass slides. An effective separation region of 7 mm by 1.8 mm is achieved on a 1 cm by 1 cm chip. A 420 μm lateral separation was achieved for 5 μm and 10 μm beads. The critical particle size for separation was found experimentally to be 8 μm, concluded from our results using 5 μm, 7 μm, 8 μm and 10 μm polystyrene beads. Diluted whole blood and blood fraction of concentrated leukocytes were also tested with the devices in agreement with blood count results. Problem of blood cell stiction to device surfaces was investigated.

Original languageEnglish (US)
Pages (from-to)851-854
Number of pages4
JournalProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
StatePublished - Oct 25 2005
Event18th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2005 Miami - Miami Beach, FL, United States
Duration: Jan 30 2005Feb 3 2005

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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