Deubiquitinases in the regulation of NF-κB signaling

Edward W. Harhaj, Vishva M. Dixit

Research output: Contribution to journalReview article

153 Citations (Scopus)

Abstract

Nuclear factor-kappa B (NF-κB) is a critical regulator of multiple biological functions including innate and adaptive immunity and cell survival. Activation of NF-κB is tightly regulated to preclude chronic signaling that may lead to persistent inflammation and cancer. Ubiquitination of key signaling molecules by E3 ubiquitin ligases has emerged as an important regulatory mechanism for NF-κB signaling. Deubiquitinases (DUBs) counteract E3 ligases and therefore play a prominent role in the downregulation of NF-κB signaling and homeostasis. Understanding the mechanisms of NF-κB downregulation by specific DUBs such as A20 and CYLD may provide therapeutic opportunities for the treatment of chronic inflammatory diseases and cancer.

Original languageEnglish (US)
Pages (from-to)22-39
Number of pages18
JournalCell Research
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2011

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NF-kappa B
Ubiquitin-Protein Ligases
Down-Regulation
Ubiquitination
Adaptive Immunity
Innate Immunity
Neoplasms
Cell Survival
Homeostasis
Chronic Disease
Deubiquitinating Enzymes
Inflammation

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Harhaj, Edward W. ; Dixit, Vishva M. / Deubiquitinases in the regulation of NF-κB signaling. In: Cell Research. 2011 ; Vol. 21, No. 1. pp. 22-39.
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Deubiquitinases in the regulation of NF-κB signaling. / Harhaj, Edward W.; Dixit, Vishva M.

In: Cell Research, Vol. 21, No. 1, 01.01.2011, p. 22-39.

Research output: Contribution to journalReview article

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