Development and early natural history of HTLV-III antibodies in persons with hemophilia

M. Elaine Eyster, J. J. Goedert, M. G. Sarngadharan, S. H. Weiss, R. C. Gallo, W. A. Blattner

    Research output: Contribution to journalArticle

    Abstract

    Antibodies to human T-cell lymphotropic virus type III (HTLV-III) were first detected in 1979 in serum samples from 30 known seropositive patients with hemophilia, over half of whom seroconverted in 1981-1982. Lymphadenopathy was present in 70% who were seropositive more than three years, compared with 10% who were seropositive three years or less. T-helper cell counts were low (307 ± 64 cells/cu mm) in the early seroconverters, and normal in the late seroconverters. T-suppressor cell counts were not related to the year of seroconversion. The long latency period after seroconversion suggests an ongoing indolent process, rather than an acute infection. It remains to be determined whether this is an aberrant part of the immune response initiated by HTLV-III antigens or the results of a chronic active HTLV-III infection.

    Original languageEnglish (US)
    Pages (from-to)2219-2223
    Number of pages5
    JournalJournal of the American Medical Association
    Volume253
    Issue number15
    DOIs
    StatePublished - Jul 11 1985

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    HIV Antibodies
    Hemophilia A
    Natural History
    HIV
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    HIV Antigens
    HIV Infections
    Antibodies
    Infection
    Serum
    Seroconversion

    All Science Journal Classification (ASJC) codes

    • Medicine(all)

    Cite this

    Eyster, M. Elaine ; Goedert, J. J. ; Sarngadharan, M. G. ; Weiss, S. H. ; Gallo, R. C. ; Blattner, W. A. / Development and early natural history of HTLV-III antibodies in persons with hemophilia. In: Journal of the American Medical Association. 1985 ; Vol. 253, No. 15. pp. 2219-2223.
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    abstract = "Antibodies to human T-cell lymphotropic virus type III (HTLV-III) were first detected in 1979 in serum samples from 30 known seropositive patients with hemophilia, over half of whom seroconverted in 1981-1982. Lymphadenopathy was present in 70{\%} who were seropositive more than three years, compared with 10{\%} who were seropositive three years or less. T-helper cell counts were low (307 ± 64 cells/cu mm) in the early seroconverters, and normal in the late seroconverters. T-suppressor cell counts were not related to the year of seroconversion. The long latency period after seroconversion suggests an ongoing indolent process, rather than an acute infection. It remains to be determined whether this is an aberrant part of the immune response initiated by HTLV-III antigens or the results of a chronic active HTLV-III infection.",
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    Development and early natural history of HTLV-III antibodies in persons with hemophilia. / Eyster, M. Elaine; Goedert, J. J.; Sarngadharan, M. G.; Weiss, S. H.; Gallo, R. C.; Blattner, W. A.

    In: Journal of the American Medical Association, Vol. 253, No. 15, 11.07.1985, p. 2219-2223.

    Research output: Contribution to journalArticle

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