Development and Therapeutic Potential of Selenazo Compounds

Ana Carolina Ruberte, Carmen Sanmartin, Carlos Aydillo, Arun K. Sharma, Daniel Plano

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Incorporation of selenium (Se) atom into small molecules can substantially enhance their antioxidant, anti-inflammatory, antimutagenic, antitumoral or chemopreventive, antiviral, antibacterial, antifungal, antiparasitic, and neuroprotective effects. Specifically, selenazo compounds have received great attention owing to their chemical properties, pharmaceutical applications, and low toxicity. In this Perspective, we compile extensive literature evidence with the description and discussion of the most recent advances in different selenazo and selenadiazo motifs as potential pharmacological candidates. We also provide some perspectives on the challenges and future directions in the advancement of these selenazo compounds, each of which could generate drug candidates for various diseases.

Original languageEnglish (US)
Pages (from-to)1473-1489
Number of pages17
JournalJournal of Medicinal Chemistry
Volume63
Issue number4
DOIs
StatePublished - Feb 27 2020

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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