TY - JOUR
T1 - Development and Therapeutic Potential of Selenazo Compounds
AU - Ruberte, Ana Carolina
AU - Sanmartin, Carmen
AU - Aydillo, Carlos
AU - Sharma, Arun K.
AU - Plano, Daniel
N1 - Funding Information:
The authors thank the Department of Pharmacology and Penn State Cancer Institute of the Penn State College of Medicine and the Plan de Investigacion de la Universidad de Navarra, PIUNA (ref 2018-19) for financial support. A.C.R. expresses her gratitude to the Asociación de Amigos de la Universidad de Navarra and Caixabank for the predoctoral fellowship. D.P. acknowledges the support of his scholarship by “José Castillejo” program granted by Spanish Government (Ministerio de Educación y Formación Profesional).
Funding Information:
Daniel Plano received his B.Sc. in Chemistry from the University of Navarra at Pamplona. He also received the European Ph.D. degree in Science (Chemistry), awarded with the Extraordinary Ph.D. issued in 2010 by the School of Science of the University of Navarra (Spain). In 2011, he received a postdoctoral fellowship from the Navarra’s Government and joined the laboratory of A. K. Sharma where he was mainly working on developing novel small drug-like molecules for cancer prevention and therapy. In 2014, he became Assistant Professor at the Department of Pharmaceutical Technology and Chemistry of the University of Navarra. Nowadays, he has been adjudged with a “José Castillejo” scholarship granted by the Spanish Government (Ministerio de Educación y Formación Profesional) to join again Dr. Sharma’s lab for 3 months.
Funding Information:
The authors thank the Department of Pharmacology and Penn State Cancer Institute of the Penn State College of Medicine and the Plan de Investigacion de la Universidad de Navarra, PIUNA (ref 2018-19) for financial support. A.C.R. expresses her gratitude to the Asociacio?n de Amigos de la Universidad de Navarra and Caixabank for the predoctoral fellowship. D.P. acknowledges the support of his scholarship by ?Jose? Castillejo program granted by Spanish Government (Ministerio de Educacio?n y Formacio?n Profesional).
Publisher Copyright:
Copyright © 2019 American Chemical Society.
PY - 2020/2/27
Y1 - 2020/2/27
N2 - Incorporation of selenium (Se) atom into small molecules can substantially enhance their antioxidant, anti-inflammatory, antimutagenic, antitumoral or chemopreventive, antiviral, antibacterial, antifungal, antiparasitic, and neuroprotective effects. Specifically, selenazo compounds have received great attention owing to their chemical properties, pharmaceutical applications, and low toxicity. In this Perspective, we compile extensive literature evidence with the description and discussion of the most recent advances in different selenazo and selenadiazo motifs as potential pharmacological candidates. We also provide some perspectives on the challenges and future directions in the advancement of these selenazo compounds, each of which could generate drug candidates for various diseases.
AB - Incorporation of selenium (Se) atom into small molecules can substantially enhance their antioxidant, anti-inflammatory, antimutagenic, antitumoral or chemopreventive, antiviral, antibacterial, antifungal, antiparasitic, and neuroprotective effects. Specifically, selenazo compounds have received great attention owing to their chemical properties, pharmaceutical applications, and low toxicity. In this Perspective, we compile extensive literature evidence with the description and discussion of the most recent advances in different selenazo and selenadiazo motifs as potential pharmacological candidates. We also provide some perspectives on the challenges and future directions in the advancement of these selenazo compounds, each of which could generate drug candidates for various diseases.
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U2 - 10.1021/acs.jmedchem.9b01152
DO - 10.1021/acs.jmedchem.9b01152
M3 - Article
C2 - 31638805
AN - SCOPUS:85074879418
SN - 0022-2623
VL - 63
SP - 1473
EP - 1489
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 4
ER -