Development of a computational model for acute ischemic stroke recanalization through cyclic aspiration

Research output: Contribution to journalArticle

Abstract

Acute ischemic stroke (AIS), the result of embolic occlusion of a cerebral artery, is responsible for 87% of the 6.5 million stroke-related deaths each year. Despite improvements from first-generation thrombectomy devices for treating AIS, 80% of eligible stroke patients will either die or suffer a major disability. In order to maximize the number of patients with good outcomes, new AIS therapies need to be developed to achieve complete reperfusion on the first pass. One such therapy that has shown promise experimentally is the application of cyclic aspiration pressure, which led to higher recanalization rates at lower pressure magnitudes. In order to investigate AIS and cyclic aspiration recanalization, an improved computational modeling framework was developed, combining a viscoelastic thromboembolus model with a cohesive zone (CZ) model for the thromboembolus–artery interface. The model was first validated against experimental displacement data of a cyclically aspirated thromboembolus analog. The CZ model parameters, including the addition of a damage accumulation model, were then investigated computationally to determine their individual effects on the thromboembolus and CZ behavior. The relaxation time and the damage model critical opening length were shown to have the greatest effect on the CZ opening and led to increased displacement that accumulated with repeated loading. Additional simulations were performed with parameters relevant to AIS including internal carotid artery dimensions and thromboemboli mechanical properties. In these AIS cases, more upstream CZ opening was observed compared to the thromboembolus analog cases and greater displacement was achieved with the lower-frequency aspiration (0.5 vs 1 Hz).

Original languageEnglish (US)
JournalBiomechanics and Modeling in Mechanobiology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Stroke
Acute
Computational Model
Cohesive Zone
Cohesive Zone Model
Arteries
Therapy
Damage Accumulation
Analogue
Reperfusion
Pressure
Viscoelastic Model
Relaxation time
Thrombectomy
Cerebral Arteries
Computational Modeling
Disability
Internal Carotid Artery
Occlusion
Relaxation Time

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Modeling and Simulation
  • Mechanical Engineering

Cite this

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title = "Development of a computational model for acute ischemic stroke recanalization through cyclic aspiration",
abstract = "Acute ischemic stroke (AIS), the result of embolic occlusion of a cerebral artery, is responsible for 87{\%} of the 6.5 million stroke-related deaths each year. Despite improvements from first-generation thrombectomy devices for treating AIS, 80{\%} of eligible stroke patients will either die or suffer a major disability. In order to maximize the number of patients with good outcomes, new AIS therapies need to be developed to achieve complete reperfusion on the first pass. One such therapy that has shown promise experimentally is the application of cyclic aspiration pressure, which led to higher recanalization rates at lower pressure magnitudes. In order to investigate AIS and cyclic aspiration recanalization, an improved computational modeling framework was developed, combining a viscoelastic thromboembolus model with a cohesive zone (CZ) model for the thromboembolus–artery interface. The model was first validated against experimental displacement data of a cyclically aspirated thromboembolus analog. The CZ model parameters, including the addition of a damage accumulation model, were then investigated computationally to determine their individual effects on the thromboembolus and CZ behavior. The relaxation time and the damage model critical opening length were shown to have the greatest effect on the CZ opening and led to increased displacement that accumulated with repeated loading. Additional simulations were performed with parameters relevant to AIS including internal carotid artery dimensions and thromboemboli mechanical properties. In these AIS cases, more upstream CZ opening was observed compared to the thromboembolus analog cases and greater displacement was achieved with the lower-frequency aspiration (0.5 vs 1 Hz).",
author = "Good, {Bryan C.} and Scott Simon and Keefe Manning and Francesco Costanzo",
year = "2019",
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N2 - Acute ischemic stroke (AIS), the result of embolic occlusion of a cerebral artery, is responsible for 87% of the 6.5 million stroke-related deaths each year. Despite improvements from first-generation thrombectomy devices for treating AIS, 80% of eligible stroke patients will either die or suffer a major disability. In order to maximize the number of patients with good outcomes, new AIS therapies need to be developed to achieve complete reperfusion on the first pass. One such therapy that has shown promise experimentally is the application of cyclic aspiration pressure, which led to higher recanalization rates at lower pressure magnitudes. In order to investigate AIS and cyclic aspiration recanalization, an improved computational modeling framework was developed, combining a viscoelastic thromboembolus model with a cohesive zone (CZ) model for the thromboembolus–artery interface. The model was first validated against experimental displacement data of a cyclically aspirated thromboembolus analog. The CZ model parameters, including the addition of a damage accumulation model, were then investigated computationally to determine their individual effects on the thromboembolus and CZ behavior. The relaxation time and the damage model critical opening length were shown to have the greatest effect on the CZ opening and led to increased displacement that accumulated with repeated loading. Additional simulations were performed with parameters relevant to AIS including internal carotid artery dimensions and thromboemboli mechanical properties. In these AIS cases, more upstream CZ opening was observed compared to the thromboembolus analog cases and greater displacement was achieved with the lower-frequency aspiration (0.5 vs 1 Hz).

AB - Acute ischemic stroke (AIS), the result of embolic occlusion of a cerebral artery, is responsible for 87% of the 6.5 million stroke-related deaths each year. Despite improvements from first-generation thrombectomy devices for treating AIS, 80% of eligible stroke patients will either die or suffer a major disability. In order to maximize the number of patients with good outcomes, new AIS therapies need to be developed to achieve complete reperfusion on the first pass. One such therapy that has shown promise experimentally is the application of cyclic aspiration pressure, which led to higher recanalization rates at lower pressure magnitudes. In order to investigate AIS and cyclic aspiration recanalization, an improved computational modeling framework was developed, combining a viscoelastic thromboembolus model with a cohesive zone (CZ) model for the thromboembolus–artery interface. The model was first validated against experimental displacement data of a cyclically aspirated thromboembolus analog. The CZ model parameters, including the addition of a damage accumulation model, were then investigated computationally to determine their individual effects on the thromboembolus and CZ behavior. The relaxation time and the damage model critical opening length were shown to have the greatest effect on the CZ opening and led to increased displacement that accumulated with repeated loading. Additional simulations were performed with parameters relevant to AIS including internal carotid artery dimensions and thromboemboli mechanical properties. In these AIS cases, more upstream CZ opening was observed compared to the thromboembolus analog cases and greater displacement was achieved with the lower-frequency aspiration (0.5 vs 1 Hz).

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