Development of a device for measuring adherence of skin grafts to the wound surface

Cheng Dong, E. Mead, R. Skalak, Y. C. Fung, J. C. Debes, R. L. Zapata-Sirvent, C. Andree, G. Greenleaf, M. Cooper, J. F. Hansbrough

Research output: Contribution to journalArticle

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Abstract

Adherence of a biological graft to the wound surface is the most important factor influencing the ultimate success of graft viability. A machine has been developed to test the adherence of biological graft materials to a substrate such as a wound surface. The peeling mode, which yields reproducible quantitative measurements of adherence, is a standard method for testing adhesives. The device is designed to continuously measure the force required to peel the graft from the substrate at a constant rate. This force is a function of the energy of adhesion per unit area of adhered surface. This device has been used to measure the peeling force of (2×2 cm) skin grafts which are applied to full-thickness wounds on mice. Results of tests on adherence of autografts on mice show that the peeling force increases significantly with time over the first 9 days of healing. Thus, this device is useful in quantitative comparison of various skin grafting techniques and artificial grafts.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalAnnals of Biomedical Engineering
Volume21
Issue number1
DOIs
StatePublished - Jan 1 1993

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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    Dong, C., Mead, E., Skalak, R., Fung, Y. C., Debes, J. C., Zapata-Sirvent, R. L., Andree, C., Greenleaf, G., Cooper, M., & Hansbrough, J. F. (1993). Development of a device for measuring adherence of skin grafts to the wound surface. Annals of Biomedical Engineering, 21(1), 51-55. https://doi.org/10.1007/BF02368164