Development of a vaginal ring for achieving physiologic levels of 17β-estradi0l in hypoestrogenic women1

Paul G. Stumpf, Joseph Maruca, Richard J. Santen, Laurence M. Demers

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The ability of polysiloxane vaginal rings containing 17β -Estradiol (E2) to deliver E2 into the systemic circulation at a steady rate over long periods of time was evaluated in castrate and postmenopausal volunteers. Standard laminar designs, used to release contraceptive gestagens, deliver low levels of E2 (about 50 pg/ml) and only for 1 month. With a modified design, E2 levels of 109 to 159 pg/ml were maintained for at least 3 months, and circulating gonadotropins were infpressed to values approaching the premenopausal range. This homogeneous design provides for physiologic replacement of E2 as well as a practical research tool for studying chronic effects of E2 in human subjects.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume54
Issue number1
DOIs
StatePublished - Jan 1982

Fingerprint

Female Contraceptive Devices
Siloxanes
Progestins
Contraceptive Agents
Gonadotropins
Volunteers
Estradiol
Research

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Stumpf, Paul G. ; Maruca, Joseph ; Santen, Richard J. ; Demers, Laurence M. / Development of a vaginal ring for achieving physiologic levels of 17β-estradi0l in hypoestrogenic women1. In: Journal of Clinical Endocrinology and Metabolism. 1982 ; Vol. 54, No. 1. pp. 173-176.
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Development of a vaginal ring for achieving physiologic levels of 17β-estradi0l in hypoestrogenic women1. / Stumpf, Paul G.; Maruca, Joseph; Santen, Richard J.; Demers, Laurence M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 54, No. 1, 01.1982, p. 173-176.

Research output: Contribution to journalArticle

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