Development of a vaginal ring for achieving physiologic levels of 17β-estradi0l in hypoestrogenic women1

Paul G. Stumpf, Joseph Maruca, Richard J. Santen, Laurence M. Demers

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The ability of polysiloxane vaginal rings containing 17β -Estradiol (E2) to deliver E2 into the systemic circulation at a steady rate over long periods of time was evaluated in castrate and postmenopausal volunteers. Standard laminar designs, used to release contraceptive gestagens, deliver low levels of E2 (about 50 pg/ml) and only for 1 month. With a modified design, E2 levels of 109 to 159 pg/ml were maintained for at least 3 months, and circulating gonadotropins were infpressed to values approaching the premenopausal range. This homogeneous design provides for physiologic replacement of E2 as well as a practical research tool for studying chronic effects of E2 in human subjects.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume54
Issue number1
DOIs
StatePublished - Jan 1982

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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