Abstract
Traditional crosslinked polyester elastomers are inherently weak, and the strategy of increasing crosslink density to improve their mechanical properties makes them brittle materials. Biodegradable polyurethanes, although strong and elastic, do not fare well in dynamic environments due to the onset of permanent deformation. The design and development of a soft, strong and completely elastic (100% recovery from deformation) material for tissue engineering still remains a challenge. Herein, we report the synthesis and evaluation of a new class of biodegradable elastomers, crosslinked urethane-doped polyesters (CUPEs), which is able to satisfy the need for soft, strong, and elastic biomaterials. Tensile strength of CUPE was as high as 41.07 ± 6.85 MPa with corresponding elongation at break of 222.66 ± 27.84%. The initial modulus ranged from 4.14 ± 1.71 MPa to 38.35 ± 4.5 MPa. Mechanical properties and degradation rates of CUPE could be controlled by varying the choice of diol used for synthesis, the polymerization conditions, as well as the concentration of urethane bonds in the polymer. The polymers demonstrated good in vitro and in vivo biocompatibilities. Preliminary hemocompatibility evaluation indicated that CUPE adhered and activated lesser number of platelets compared to PLLA. Good mechanical properties and easy processability make these materials well suited for soft tissue engineering applications. The introduction of CUPEs provides new avenues to meet the versatile requirements of tissue engineering and other biomedical applications.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4637-4649 |
| Number of pages | 13 |
| Journal | Biomaterials |
| Volume | 29 |
| Issue number | 35 |
| DOIs | |
| State | Published - Dec 1 2008 |
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All Science Journal Classification (ASJC) codes
- Bioengineering
- Ceramics and Composites
- Biophysics
- Biomaterials
- Mechanics of Materials
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Development of biodegradable crosslinked urethane-doped polyester elastomers. / Dey, Jagannath; Xu, Hao; Shen, Jinhui; Thevenot, Paul; Gondi, Sudershan R.; Nguyen, Kytai T.; Sumerlin, Brent S.; Tang, Liping; Yang, Jian.
In: Biomaterials, Vol. 29, No. 35, 01.12.2008, p. 4637-4649.Research output: Contribution to journal › Article
TY - JOUR
T1 - Development of biodegradable crosslinked urethane-doped polyester elastomers
AU - Dey, Jagannath
AU - Xu, Hao
AU - Shen, Jinhui
AU - Thevenot, Paul
AU - Gondi, Sudershan R.
AU - Nguyen, Kytai T.
AU - Sumerlin, Brent S.
AU - Tang, Liping
AU - Yang, Jian
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Traditional crosslinked polyester elastomers are inherently weak, and the strategy of increasing crosslink density to improve their mechanical properties makes them brittle materials. Biodegradable polyurethanes, although strong and elastic, do not fare well in dynamic environments due to the onset of permanent deformation. The design and development of a soft, strong and completely elastic (100% recovery from deformation) material for tissue engineering still remains a challenge. Herein, we report the synthesis and evaluation of a new class of biodegradable elastomers, crosslinked urethane-doped polyesters (CUPEs), which is able to satisfy the need for soft, strong, and elastic biomaterials. Tensile strength of CUPE was as high as 41.07 ± 6.85 MPa with corresponding elongation at break of 222.66 ± 27.84%. The initial modulus ranged from 4.14 ± 1.71 MPa to 38.35 ± 4.5 MPa. Mechanical properties and degradation rates of CUPE could be controlled by varying the choice of diol used for synthesis, the polymerization conditions, as well as the concentration of urethane bonds in the polymer. The polymers demonstrated good in vitro and in vivo biocompatibilities. Preliminary hemocompatibility evaluation indicated that CUPE adhered and activated lesser number of platelets compared to PLLA. Good mechanical properties and easy processability make these materials well suited for soft tissue engineering applications. The introduction of CUPEs provides new avenues to meet the versatile requirements of tissue engineering and other biomedical applications.
AB - Traditional crosslinked polyester elastomers are inherently weak, and the strategy of increasing crosslink density to improve their mechanical properties makes them brittle materials. Biodegradable polyurethanes, although strong and elastic, do not fare well in dynamic environments due to the onset of permanent deformation. The design and development of a soft, strong and completely elastic (100% recovery from deformation) material for tissue engineering still remains a challenge. Herein, we report the synthesis and evaluation of a new class of biodegradable elastomers, crosslinked urethane-doped polyesters (CUPEs), which is able to satisfy the need for soft, strong, and elastic biomaterials. Tensile strength of CUPE was as high as 41.07 ± 6.85 MPa with corresponding elongation at break of 222.66 ± 27.84%. The initial modulus ranged from 4.14 ± 1.71 MPa to 38.35 ± 4.5 MPa. Mechanical properties and degradation rates of CUPE could be controlled by varying the choice of diol used for synthesis, the polymerization conditions, as well as the concentration of urethane bonds in the polymer. The polymers demonstrated good in vitro and in vivo biocompatibilities. Preliminary hemocompatibility evaluation indicated that CUPE adhered and activated lesser number of platelets compared to PLLA. Good mechanical properties and easy processability make these materials well suited for soft tissue engineering applications. The introduction of CUPEs provides new avenues to meet the versatile requirements of tissue engineering and other biomedical applications.
UR - http://www.scopus.com/inward/record.url?scp=53149114818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53149114818&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2008.08.020
DO - 10.1016/j.biomaterials.2008.08.020
M3 - Article
C2 - 18801566
AN - SCOPUS:53149114818
VL - 29
SP - 4637
EP - 4649
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 35
ER -