Development of biodegradable polyphosphazene- Nanohydroxyapatlte composite nanofibers via electrospinning

Subhabrata Bhattacharyya, Lakshmi S. Nair, Anurima Singh, Nick R. Krogman, Jared Bender, Yaser E. Greish, Paul W. Brown, Harry R. Allcock, Cato T. Laurencin

Research output: Contribution to journalConference article

16 Citations (Scopus)

Abstract

Biodegradable polymeric nanofibers are of great interest as scaffolds for tissue engineering and drug delivery due to their extremely high surface area, high aspect ratio and similarity in structure to the extracellular matrix (ECM). Polyphosphazenes due to their synthetic flexibility, wide range of physico-chemical properties, non-toxic and neutral degradation products and excellent biocompatibility are suitable candidates for biomedical applications. The objective of the present study was to develop and evaluate composite nanofibers of a biodegradable polyphosphazene, poly[bis(ethyl alanato)phosphazene] (PNEA) and nanocrystals of hydroxyapatite (nHAp) via electrospinning. A suspension of nHAp in dimethyl formamide (DMF) sonicated with PNEA solution in tetrahydrofuran (THF) was used to develop composite nanofiber matrices via electrospinning at ambient conditions. In the present study the theoretical loading of nHAp was varied from 50%-90% (w/w) to PNEA. The nHAp content (actual loading of nHAp) of the composite nanofibers was determined by gravimetric estimation. The composite nanofibers were characterized by transmission electron microscopy (TEM), gravimetry and energy dispersive X-ray mapping. This study demonstrated the feasibility of developing novel composite nanofibers of biodegradable polyphosphazenes with more than 50% (w/w) loading of nHAp on and within the nanofibers.

Original languageEnglish (US)
Article numberAA4.2
Pages (from-to)91-96
Number of pages6
JournalMaterials Research Society Symposium Proceedings
Volume845
StatePublished - Jun 20 2005
EventNanoscale Materials Science in Biology and Medicine - Boston, MA, United States
Duration: Nov 28 2004Dec 2 2004

Fingerprint

Electrospinning
Nanofibers
Durapatite
Hydroxyapatite
nanocrystals
Nanocrystals
composite materials
Composite materials
phosphazene
gravimetry
tissue engineering
biocompatibility
matrices
tetrahydrofuran
high aspect ratio
Gravimetric analysis
chemical properties
Dimethylformamide
Scaffolds (biology)
poly(phosphazene)

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Bhattacharyya, S., Nair, L. S., Singh, A., Krogman, N. R., Bender, J., Greish, Y. E., ... Laurencin, C. T. (2005). Development of biodegradable polyphosphazene- Nanohydroxyapatlte composite nanofibers via electrospinning. Materials Research Society Symposium Proceedings, 845, 91-96. [AA4.2].
Bhattacharyya, Subhabrata ; Nair, Lakshmi S. ; Singh, Anurima ; Krogman, Nick R. ; Bender, Jared ; Greish, Yaser E. ; Brown, Paul W. ; Allcock, Harry R. ; Laurencin, Cato T. / Development of biodegradable polyphosphazene- Nanohydroxyapatlte composite nanofibers via electrospinning. In: Materials Research Society Symposium Proceedings. 2005 ; Vol. 845. pp. 91-96.
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Bhattacharyya, S, Nair, LS, Singh, A, Krogman, NR, Bender, J, Greish, YE, Brown, PW, Allcock, HR & Laurencin, CT 2005, 'Development of biodegradable polyphosphazene- Nanohydroxyapatlte composite nanofibers via electrospinning', Materials Research Society Symposium Proceedings, vol. 845, AA4.2, pp. 91-96.

Development of biodegradable polyphosphazene- Nanohydroxyapatlte composite nanofibers via electrospinning. / Bhattacharyya, Subhabrata; Nair, Lakshmi S.; Singh, Anurima; Krogman, Nick R.; Bender, Jared; Greish, Yaser E.; Brown, Paul W.; Allcock, Harry R.; Laurencin, Cato T.

In: Materials Research Society Symposium Proceedings, Vol. 845, AA4.2, 20.06.2005, p. 91-96.

Research output: Contribution to journalConference article

TY - JOUR

T1 - Development of biodegradable polyphosphazene- Nanohydroxyapatlte composite nanofibers via electrospinning

AU - Bhattacharyya, Subhabrata

AU - Nair, Lakshmi S.

AU - Singh, Anurima

AU - Krogman, Nick R.

AU - Bender, Jared

AU - Greish, Yaser E.

AU - Brown, Paul W.

AU - Allcock, Harry R.

AU - Laurencin, Cato T.

PY - 2005/6/20

Y1 - 2005/6/20

N2 - Biodegradable polymeric nanofibers are of great interest as scaffolds for tissue engineering and drug delivery due to their extremely high surface area, high aspect ratio and similarity in structure to the extracellular matrix (ECM). Polyphosphazenes due to their synthetic flexibility, wide range of physico-chemical properties, non-toxic and neutral degradation products and excellent biocompatibility are suitable candidates for biomedical applications. The objective of the present study was to develop and evaluate composite nanofibers of a biodegradable polyphosphazene, poly[bis(ethyl alanato)phosphazene] (PNEA) and nanocrystals of hydroxyapatite (nHAp) via electrospinning. A suspension of nHAp in dimethyl formamide (DMF) sonicated with PNEA solution in tetrahydrofuran (THF) was used to develop composite nanofiber matrices via electrospinning at ambient conditions. In the present study the theoretical loading of nHAp was varied from 50%-90% (w/w) to PNEA. The nHAp content (actual loading of nHAp) of the composite nanofibers was determined by gravimetric estimation. The composite nanofibers were characterized by transmission electron microscopy (TEM), gravimetry and energy dispersive X-ray mapping. This study demonstrated the feasibility of developing novel composite nanofibers of biodegradable polyphosphazenes with more than 50% (w/w) loading of nHAp on and within the nanofibers.

AB - Biodegradable polymeric nanofibers are of great interest as scaffolds for tissue engineering and drug delivery due to their extremely high surface area, high aspect ratio and similarity in structure to the extracellular matrix (ECM). Polyphosphazenes due to their synthetic flexibility, wide range of physico-chemical properties, non-toxic and neutral degradation products and excellent biocompatibility are suitable candidates for biomedical applications. The objective of the present study was to develop and evaluate composite nanofibers of a biodegradable polyphosphazene, poly[bis(ethyl alanato)phosphazene] (PNEA) and nanocrystals of hydroxyapatite (nHAp) via electrospinning. A suspension of nHAp in dimethyl formamide (DMF) sonicated with PNEA solution in tetrahydrofuran (THF) was used to develop composite nanofiber matrices via electrospinning at ambient conditions. In the present study the theoretical loading of nHAp was varied from 50%-90% (w/w) to PNEA. The nHAp content (actual loading of nHAp) of the composite nanofibers was determined by gravimetric estimation. The composite nanofibers were characterized by transmission electron microscopy (TEM), gravimetry and energy dispersive X-ray mapping. This study demonstrated the feasibility of developing novel composite nanofibers of biodegradable polyphosphazenes with more than 50% (w/w) loading of nHAp on and within the nanofibers.

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M3 - Conference article

AN - SCOPUS:20344394914

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JO - Materials Research Society Symposium - Proceedings

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Bhattacharyya S, Nair LS, Singh A, Krogman NR, Bender J, Greish YE et al. Development of biodegradable polyphosphazene- Nanohydroxyapatlte composite nanofibers via electrospinning. Materials Research Society Symposium Proceedings. 2005 Jun 20;845:91-96. AA4.2.