Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: Synthesis and in vivo evaluation in S180-bearing mice

Yuji Wang, Lei Wei, Ming Zhao, Shenghui Mei, Meiqing Zheng, Yifan Yang, Hong Wang, Gong Chen, Shiqi Peng

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A series of chelants (3a-s) composed of a glucosyl tail, an amino acid side chain and a dithiocarbamate group were designed, synthesized, and evaluated. By co-administering with cisplatin, 3a-s were able to decrease the accumulation of platinum in the organs, maintain the accumulation of platinum in the tumor tissues, and increase the urinary and fecal platinum, as well as increasing the voided volume of the treated S180-bearing mice. Compared to S180-bearing mice treated with cisplatin alone, the co-administered mice lost no spleen, kidney, liver, brain and heart weights, lost less body weight, and showed no increase in tumor weight.

Original languageEnglish (US)
Pages (from-to)1212-1217
Number of pages6
JournalMetallomics
Volume3
Issue number11
DOIs
StatePublished - Nov 1 2011

All Science Journal Classification (ASJC) codes

  • Chemistry (miscellaneous)
  • Biophysics
  • Biomaterials
  • Biochemistry
  • Metals and Alloys

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