Development of Isoselenocyanate Compounds' Syntheses and Biological Applications

Emily E. Frieben, Shantu Amin, Arun K. Sharma

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

As the number of cases and cancer-related deaths are projected to rise in upcoming years, it is urgent to find ways to prevent or treat cancer. As such, food-derived products have gained attention as potential chemopreventive agents due to their availability, safety, and low cost. Isothiocyanates, the breakdown products of sulfur-containing glucosinolates in cruciferous vegetables, have shown substantial anticarcinogenic and chemopreventive activities for different human cancers. Furthermore, organoselenium compounds are known to exhibit chemopreventive and chemotherapeutic activity; moreover, these compounds are more effective anticancer agents than their sulfur isosteres. Hence, isothiocyanates have been modified to yield isoselenocyanates, which are more cytotoxic toward cancer cells when compared to their corresponding sulfur analogues. Herein, the synthesis and development of isoselenocyanates as novel treatments for cancer and other diseases are reviewed, highlighting the diverse chemistry and computational studies of this class of compounds as well as their pertinent biological applications.

Original languageEnglish (US)
Pages (from-to)5261-5275
Number of pages15
JournalJournal of Medicinal Chemistry
Volume62
Issue number11
DOIs
StatePublished - Jun 13 2019

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

Fingerprint Dive into the research topics of 'Development of Isoselenocyanate Compounds' Syntheses and Biological Applications'. Together they form a unique fingerprint.

  • Cite this