Development of liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry for analysis of halogenated flame retardants in wastewater

Simon Ningsun Zhou, Eric J. Reiner, Chris Marvin, Paul Helm, Nicole Riddell, Frank Dorman, Michelle Misselwitz, Li Shen, Patrick Crozier, Karen MacPherson, Ian D. Brindle

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Until recently, atmospheric pressure photoionization (APPI) has typically been used for the determination of non-polar halogenated flame retardants (HFRs) by liquid chromatography (LC) tandem mass spectrometry. In this study, we demonstrated the feasibility of utilizing liquid chromatography atmospheric pressure chemical ionization (APCI) tandem mass spectrometry (LC-APCI-MS/MS) for analysis of 38 HFRs. This developed method offered three advantages: simplicity, rapidity, and high sensitivity. Compared with APPI, APCI does not require a UV lamp and a dopant reagent to assist atmospheric pressure ionization. All the isomers and the isobaric compounds were well resolved within 14-min LC separation time. Excellent instrument detection limits (6.1 pg on average with 2.0 μL injection) were observed. The APCI mechanism was also investigated. The method developed has been applied to the screening of wastewater samples for screening purpose, with concentrations determined by LC-APCI-MS/MS agreeing with data obtained via gas chromatography high resolution mass spectrometry.

Original languageEnglish (US)
Pages (from-to)1311-1320
Number of pages10
JournalAnalytical and Bioanalytical Chemistry
Volume396
Issue number3
DOIs
StatePublished - 2010

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry

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