Development of novel biodegradable amino acid ester based polyphosphazene-hydroxyapatite composites for bone tissue engineering

Swaminathan Sethuraman, Lakshmi S. Nair, Anurima Singh, Jared D. Bender, Yaser E. Greish, Paul W. Brown, Harry R. Allcock, Cato T. Laurencin

Research output: Contribution to journalConference article

5 Citations (Scopus)

Abstract

Hydroxyapatite formed from low temperature setting calcium phosphate cements (CPC) are currently been used for various orthopaedic applications. CPCs are attractive candidates for the development of scaffolds for bone tissue engineering, since they are moldable, resorbable, set at physiological temperature without the use of toxic chemicals, and can be processed in an operating room setting. However they may have mechanical disadvantages which seriously limit them to non-load bearing orthopaedic applications. The aim of the present study was to develop composites from polyphosphazenes and calcium deficient hydroxyapatite precursors to form poorly crystalline hydroxyapatite-polymer composites. Composites were formed from calcium deficient hydroxyapatite precursors (Ca/P - 1.5, 1.6) and biodegradable polyphosphazenes, poly[bis(ethyl alanato)phosphazene] (PNEA) and poly[(50%ethyl alanato) (50%methyl phenoxy)phosphazene] (PNEA50mPh50) at physiological temperature. The results demonstrated that poorly crystalline hydroxyapatite that resembled the mineral component of bone was formed in the presence of biodegradable polyphosphazenes. The surface morphology of all the four composites was identical with a porous microstructure. The composites supported the adhesion and proliferation of osteoblast like MC3T3-E1 cells making them potential candidates for bone tissue engineering.

Original languageEnglish (US)
Article numberAA5.22
Pages (from-to)291-296
Number of pages6
JournalMaterials Research Society Symposium Proceedings
Volume845
StatePublished - Jun 20 2005
EventNanoscale Materials Science in Biology and Medicine - Boston, MA, United States
Duration: Nov 28 2004Dec 2 2004

Fingerprint

tissue engineering
Durapatite
Hydroxyapatite
Tissue engineering
bones
amino acids
Amino acids
esters
Esters
Bone
Amino Acids
composite materials
phosphazene
Composite materials
orthopedics
Orthopedics
calcium
Calcium
Bearings (structural)
Crystalline materials

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Sethuraman, S., Nair, L. S., Singh, A., Bender, J. D., Greish, Y. E., Brown, P. W., ... Laurencin, C. T. (2005). Development of novel biodegradable amino acid ester based polyphosphazene-hydroxyapatite composites for bone tissue engineering. Materials Research Society Symposium Proceedings, 845, 291-296. [AA5.22].
Sethuraman, Swaminathan ; Nair, Lakshmi S. ; Singh, Anurima ; Bender, Jared D. ; Greish, Yaser E. ; Brown, Paul W. ; Allcock, Harry R. ; Laurencin, Cato T. / Development of novel biodegradable amino acid ester based polyphosphazene-hydroxyapatite composites for bone tissue engineering. In: Materials Research Society Symposium Proceedings. 2005 ; Vol. 845. pp. 291-296.
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abstract = "Hydroxyapatite formed from low temperature setting calcium phosphate cements (CPC) are currently been used for various orthopaedic applications. CPCs are attractive candidates for the development of scaffolds for bone tissue engineering, since they are moldable, resorbable, set at physiological temperature without the use of toxic chemicals, and can be processed in an operating room setting. However they may have mechanical disadvantages which seriously limit them to non-load bearing orthopaedic applications. The aim of the present study was to develop composites from polyphosphazenes and calcium deficient hydroxyapatite precursors to form poorly crystalline hydroxyapatite-polymer composites. Composites were formed from calcium deficient hydroxyapatite precursors (Ca/P - 1.5, 1.6) and biodegradable polyphosphazenes, poly[bis(ethyl alanato)phosphazene] (PNEA) and poly[(50{\%}ethyl alanato) (50{\%}methyl phenoxy)phosphazene] (PNEA50mPh50) at physiological temperature. The results demonstrated that poorly crystalline hydroxyapatite that resembled the mineral component of bone was formed in the presence of biodegradable polyphosphazenes. The surface morphology of all the four composites was identical with a porous microstructure. The composites supported the adhesion and proliferation of osteoblast like MC3T3-E1 cells making them potential candidates for bone tissue engineering.",
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Sethuraman, S, Nair, LS, Singh, A, Bender, JD, Greish, YE, Brown, PW, Allcock, HR & Laurencin, CT 2005, 'Development of novel biodegradable amino acid ester based polyphosphazene-hydroxyapatite composites for bone tissue engineering', Materials Research Society Symposium Proceedings, vol. 845, AA5.22, pp. 291-296.

Development of novel biodegradable amino acid ester based polyphosphazene-hydroxyapatite composites for bone tissue engineering. / Sethuraman, Swaminathan; Nair, Lakshmi S.; Singh, Anurima; Bender, Jared D.; Greish, Yaser E.; Brown, Paul W.; Allcock, Harry R.; Laurencin, Cato T.

In: Materials Research Society Symposium Proceedings, Vol. 845, AA5.22, 20.06.2005, p. 291-296.

Research output: Contribution to journalConference article

TY - JOUR

T1 - Development of novel biodegradable amino acid ester based polyphosphazene-hydroxyapatite composites for bone tissue engineering

AU - Sethuraman, Swaminathan

AU - Nair, Lakshmi S.

AU - Singh, Anurima

AU - Bender, Jared D.

AU - Greish, Yaser E.

AU - Brown, Paul W.

AU - Allcock, Harry R.

AU - Laurencin, Cato T.

PY - 2005/6/20

Y1 - 2005/6/20

N2 - Hydroxyapatite formed from low temperature setting calcium phosphate cements (CPC) are currently been used for various orthopaedic applications. CPCs are attractive candidates for the development of scaffolds for bone tissue engineering, since they are moldable, resorbable, set at physiological temperature without the use of toxic chemicals, and can be processed in an operating room setting. However they may have mechanical disadvantages which seriously limit them to non-load bearing orthopaedic applications. The aim of the present study was to develop composites from polyphosphazenes and calcium deficient hydroxyapatite precursors to form poorly crystalline hydroxyapatite-polymer composites. Composites were formed from calcium deficient hydroxyapatite precursors (Ca/P - 1.5, 1.6) and biodegradable polyphosphazenes, poly[bis(ethyl alanato)phosphazene] (PNEA) and poly[(50%ethyl alanato) (50%methyl phenoxy)phosphazene] (PNEA50mPh50) at physiological temperature. The results demonstrated that poorly crystalline hydroxyapatite that resembled the mineral component of bone was formed in the presence of biodegradable polyphosphazenes. The surface morphology of all the four composites was identical with a porous microstructure. The composites supported the adhesion and proliferation of osteoblast like MC3T3-E1 cells making them potential candidates for bone tissue engineering.

AB - Hydroxyapatite formed from low temperature setting calcium phosphate cements (CPC) are currently been used for various orthopaedic applications. CPCs are attractive candidates for the development of scaffolds for bone tissue engineering, since they are moldable, resorbable, set at physiological temperature without the use of toxic chemicals, and can be processed in an operating room setting. However they may have mechanical disadvantages which seriously limit them to non-load bearing orthopaedic applications. The aim of the present study was to develop composites from polyphosphazenes and calcium deficient hydroxyapatite precursors to form poorly crystalline hydroxyapatite-polymer composites. Composites were formed from calcium deficient hydroxyapatite precursors (Ca/P - 1.5, 1.6) and biodegradable polyphosphazenes, poly[bis(ethyl alanato)phosphazene] (PNEA) and poly[(50%ethyl alanato) (50%methyl phenoxy)phosphazene] (PNEA50mPh50) at physiological temperature. The results demonstrated that poorly crystalline hydroxyapatite that resembled the mineral component of bone was formed in the presence of biodegradable polyphosphazenes. The surface morphology of all the four composites was identical with a porous microstructure. The composites supported the adhesion and proliferation of osteoblast like MC3T3-E1 cells making them potential candidates for bone tissue engineering.

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M3 - Conference article

AN - SCOPUS:20344387470

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EP - 296

JO - Materials Research Society Symposium - Proceedings

JF - Materials Research Society Symposium - Proceedings

SN - 0272-9172

M1 - AA5.22

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