Development of novel submicron textured polyether(urethane urea) for decreasing platelet adhesion

Keith R. Milner, Christopher Siedlecki, Alan J. Snyder

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Ventricular assist devices have proven to be a useful clinical option for providing circulatory support as a bridge to transplantation and a mode of destination therapy. Thromboembolism is prevented by designing devices that use blood interfaces that either encourage biological material deposition and strong adhesion, or discourage deposition via surface chemistry, surface finish, and fluid flow fields. Minimum continuous or periodic wall shear forces and maximum time at reduced shear are important, and sometimes difficult-to-satisfy, design constraints. We present an approach to reducing platelet adhesion via surface topography, reducing surface area for platelet-material interaction. Large areas of polyether(urethane urea) were textured with two different sizes of ordered pillar arrays via two-stage replication molding without affecting surface chemistry. Pillars had subplatelet dimensions designed to reduce the surface area a platelet may contact. Platelet adhesion was assessed in a physiologically relevant shear stress range from 0-10 dyn/cm2 using a rotating disk and compared to smooth control. Adhesion was highest from 0-5 dyn/cm 2. Surface texturing reduced platelet adhesion without increasing platelet activation in bulk suspension. This study demonstrates that material surface texture is an additional variable that may be used to reduce platelet adhesion under low shear stresses potentially reducing thromboembolism.

Original languageEnglish (US)
Pages (from-to)578-584
Number of pages7
JournalASAIO Journal
Volume51
Issue number5
DOIs
StatePublished - Sep 1 2005

Fingerprint

Polyethers
Platelets
Urea
Blood Platelets
Adhesion
Thromboembolism
Surface chemistry
Shear stress
Heart-Assist Devices
Platelet Activation
Shear walls
Texturing
Rotating disks
Surface topography
polyetherurethane
Suspensions
Molding
Biological materials
Transplantation
Flow of fluids

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

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Development of novel submicron textured polyether(urethane urea) for decreasing platelet adhesion. / Milner, Keith R.; Siedlecki, Christopher; Snyder, Alan J.

In: ASAIO Journal, Vol. 51, No. 5, 01.09.2005, p. 578-584.

Research output: Contribution to journalArticle

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