Pluronic® polymers were screened for binding affinity to oligoribonucleotides (ORN), also termed OLIGOS, using fluorescence techniques. F127 (Mw 12600 g/mole) proved to have the strongest binding affinity. Urethane linkages were introduced into F127 and two other Pluronics, F38 (Mw 4700 glmole) and F77 (Mw 6600 g/mole), to prepare polymers that were multiples of their respective initial molecular weights. A series of these polyurethane Pluronics were screened for binding affinity. Fluorescence studies showed a relationship between the molecular weight of the P0 units and the binding affinity in the structures of the newly synthesized poly Pluronics especially in the case of F77. Light scattering confirmed the binding affinity between the oligo and F77 polymers. Particle size analysis showed an exponential increase until the critical micelle concentration. Other analogs of these polymers also studied for their binding affinity were a poly(amino ester) and protective, interactive, noncondensing polymers (PINC).