Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds

Michele M. Schantz, Bruce A. Benner, N. Alan Heckert, Lane C. Sander, Katherine E. Sharpless, Stacy S. Vander Pol, Y. Vasquez, M. Villegas, Stephen A. Wise, K. Udeni Alwis, Benjamin C. Blount, Antonia M. Calafat, Zheng Li, Manori J. Silva, Xiaoyun Ye, Éric Gaudreau, Donald G. Patterson, Andreas Sjödin

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Two new Standard Reference Materials (SRMs), SRM 3672 Organic Contaminants in Smokers' Urine (Frozen) and SRM 3673 Organic Contaminants in Non-Smokers' Urine (Frozen), have been developed in support of studies for assessment of human exposure to select organic environmental contaminants. Collaborations among three organizations resulted in certified values for 11 hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and reference values for 11 phthalate metabolites, 8 environmental phenols and parabens, and 24 volatile organic compound (VOC) metabolites. Reference values are also available for creatinine and the free forms of caffeine, theobromine, ibuprofen, nicotine, cotinine, and 3-hydroxycotinine. These are the first urine Certified Reference Materials characterized for metabolites of organic environmental contaminants. Noteworthy, the mass fractions of the environmental organic contaminants in the two SRMs are within the ranges reported in population survey studies such as the National Health and Nutrition Examination Survey (NHANES) and the Canadian Health Measures Survey (CHMS). These SRMs will be useful as quality control samples for ensuring compatibility of results among population survey studies and will fill a void to assess the accuracy of analytical methods used in studies monitoring human exposure to these organic environmental contaminants. [Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)2945-2954
Number of pages10
JournalAnalytical and Bioanalytical Chemistry
Volume407
Issue number11
DOIs
StatePublished - Apr 3 2015

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry

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