Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis

R. Levenson, D. Housman

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Abstract

The relationship between protein synthesis and commitment to terminal erythroid differentiation by dimethylsulfoxide-treated murine erythroleukemia (MEL) cells has been studied. Treatment with cycloheximide blocks the commitment of MEL cells. The effects of cycloheximide are completely reversible, however. Treatment of MEL cells before commitment delays commitment for a period of time equal to the length of inhibitor treatment. Puromycin exerts a similar effect on the commitment of MEL cells. These results indicate that there is a continuous requirement for protein synthesis before the commitment event.

Original languageEnglish (US)
Pages (from-to)715-725
Number of pages11
JournalJournal of Cell Biology
Volume82
Issue number3
DOIs
Publication statusPublished - Jan 1 1979

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All Science Journal Classification (ASJC) codes

  • Cell Biology

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