Developmental regulation of the dopamine D1 receptor in human caudate and putamen

Deidra M. Montague, Cindy P. Lawler, Richard B. Mailman, John H. Gilmore

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Perturbations in the developmental regulation of the dopaminergic system have been hypothesized to participate in the age-dependent onset of schizophrenia. Although data from studies of non-human primates suggest that dopamine D1-like receptors decrease during adolescence, less information is available concerning changes in human brain. The present study employed quantitative receptor autoradiography to measure D1-like receptor density and affinity in human caudate and putamen. Samples were obtained postmortem from 15 subjects (9 weeks to 49 years), and grouped a priori into three classes: infants, adolescents, and adults. Receptor density and affinity were assessed by saturation binding with [3H]-SCH23390, a D1 receptor antagonist. A decrease in D1 receptor density was observed from infancy to adulthood, with no change in receptor affinity. The temporal pattern of D1- like receptor expression during maturation may play a role in the interaction of dopamine with other neurotransmitter systems, and in the occurrence and pharmacotherapy of neurological and neuropsychiatric disorders.

Original languageEnglish (US)
Pages (from-to)641-649
Number of pages9
JournalNeuropsychopharmacology
Volume21
Issue number5
DOIs
StatePublished - Nov 1999

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health

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