Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products

Lucinda J. England, Kjersti Aagaard, Michele Bloch, Kevin Conway, Kelly Cosgrove, Rachel Grana, Thomas J. Gould, Dorothy Hatsukami, Frances Jensen, Denise Kandel, Bruce Lanphear, Frances Leslie, James R. Pauly, Jenae Neiderhiser, Mark Rubinstein, Theodore A. Slotkin, Eliot Spindel, Laura Stroud, Lauren Wakschlag

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

While the health risks associated with adult cigarette smoking have been well described, effects of nicotine exposure during periods of developmental vulnerability are often overlooked. Using MEDLINE and PubMed literature searches, books, reports and expert opinion, a transdisciplinary group of scientists reviewed human and animal research on the health effects of exposure to nicotine during pregnancy and adolescence. A synthesis of this research supports that nicotine contributes critically to adverse effects of gestational tobacco exposure, including reduced pulmonary function, auditory processing defects, impaired infant cardiorespiratory function, and may contribute to cognitive and behavioral deficits in later life. Nicotine exposure during adolescence is associated with deficits in working memory, attention, and auditory processing, as well as increased impulsivity and anxiety. Finally, recent animal studies suggest that nicotine has a priming effect that increases addiction liability for other drugs. The evidence that nicotine adversely affects fetal and adolescent development is sufficient to warrant public health measures to protect pregnant women, children, and adolescents from nicotine exposure.

Original languageEnglish (US)
Pages (from-to)176-189
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
Volume72
DOIs
StatePublished - Jan 1 2017

Fingerprint

Nicotine
Tobacco Products
Adolescent Development
Impulsive Behavior
Health
Expert Testimony
Fetal Development
Short-Term Memory
PubMed
MEDLINE
Tobacco
Pregnant Women
Anxiety
Public Health
Smoking
Pregnancy
Lung
Research
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

England, Lucinda J. ; Aagaard, Kjersti ; Bloch, Michele ; Conway, Kevin ; Cosgrove, Kelly ; Grana, Rachel ; Gould, Thomas J. ; Hatsukami, Dorothy ; Jensen, Frances ; Kandel, Denise ; Lanphear, Bruce ; Leslie, Frances ; Pauly, James R. ; Neiderhiser, Jenae ; Rubinstein, Mark ; Slotkin, Theodore A. ; Spindel, Eliot ; Stroud, Laura ; Wakschlag, Lauren. / Developmental toxicity of nicotine : A transdisciplinary synthesis and implications for emerging tobacco products. In: Neuroscience and Biobehavioral Reviews. 2017 ; Vol. 72. pp. 176-189.
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author = "England, {Lucinda J.} and Kjersti Aagaard and Michele Bloch and Kevin Conway and Kelly Cosgrove and Rachel Grana and Gould, {Thomas J.} and Dorothy Hatsukami and Frances Jensen and Denise Kandel and Bruce Lanphear and Frances Leslie and Pauly, {James R.} and Jenae Neiderhiser and Mark Rubinstein and Slotkin, {Theodore A.} and Eliot Spindel and Laura Stroud and Lauren Wakschlag",
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England, LJ, Aagaard, K, Bloch, M, Conway, K, Cosgrove, K, Grana, R, Gould, TJ, Hatsukami, D, Jensen, F, Kandel, D, Lanphear, B, Leslie, F, Pauly, JR, Neiderhiser, J, Rubinstein, M, Slotkin, TA, Spindel, E, Stroud, L & Wakschlag, L 2017, 'Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products', Neuroscience and Biobehavioral Reviews, vol. 72, pp. 176-189. https://doi.org/10.1016/j.neubiorev.2016.11.013

Developmental toxicity of nicotine : A transdisciplinary synthesis and implications for emerging tobacco products. / England, Lucinda J.; Aagaard, Kjersti; Bloch, Michele; Conway, Kevin; Cosgrove, Kelly; Grana, Rachel; Gould, Thomas J.; Hatsukami, Dorothy; Jensen, Frances; Kandel, Denise; Lanphear, Bruce; Leslie, Frances; Pauly, James R.; Neiderhiser, Jenae; Rubinstein, Mark; Slotkin, Theodore A.; Spindel, Eliot; Stroud, Laura; Wakschlag, Lauren.

In: Neuroscience and Biobehavioral Reviews, Vol. 72, 01.01.2017, p. 176-189.

Research output: Contribution to journalReview article

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T1 - Developmental toxicity of nicotine

T2 - A transdisciplinary synthesis and implications for emerging tobacco products

AU - England, Lucinda J.

AU - Aagaard, Kjersti

AU - Bloch, Michele

AU - Conway, Kevin

AU - Cosgrove, Kelly

AU - Grana, Rachel

AU - Gould, Thomas J.

AU - Hatsukami, Dorothy

AU - Jensen, Frances

AU - Kandel, Denise

AU - Lanphear, Bruce

AU - Leslie, Frances

AU - Pauly, James R.

AU - Neiderhiser, Jenae

AU - Rubinstein, Mark

AU - Slotkin, Theodore A.

AU - Spindel, Eliot

AU - Stroud, Laura

AU - Wakschlag, Lauren

PY - 2017/1/1

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N2 - While the health risks associated with adult cigarette smoking have been well described, effects of nicotine exposure during periods of developmental vulnerability are often overlooked. Using MEDLINE and PubMed literature searches, books, reports and expert opinion, a transdisciplinary group of scientists reviewed human and animal research on the health effects of exposure to nicotine during pregnancy and adolescence. A synthesis of this research supports that nicotine contributes critically to adverse effects of gestational tobacco exposure, including reduced pulmonary function, auditory processing defects, impaired infant cardiorespiratory function, and may contribute to cognitive and behavioral deficits in later life. Nicotine exposure during adolescence is associated with deficits in working memory, attention, and auditory processing, as well as increased impulsivity and anxiety. Finally, recent animal studies suggest that nicotine has a priming effect that increases addiction liability for other drugs. The evidence that nicotine adversely affects fetal and adolescent development is sufficient to warrant public health measures to protect pregnant women, children, and adolescents from nicotine exposure.

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JO - Neuroscience and Biobehavioral Reviews

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