Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation

Basma Hashmi, Lauren D. Zarzar, Tadanori Mammoto, Akiko Mammoto, Amanda Jiang, Joanna Aizenberg, Donald E. Ingber

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A biologically inspired thermoresponsive polymer has been developed that mechanically induces tooth differentiation in vitro and in vivo by promoting mesenchymal cell compaction as seen in each pore of the scaffold. This normally occurs during the physiological mesenchymal condensation response that triggers tooth formation in the embryo.

Original languageEnglish (US)
Pages (from-to)3253-3257
Number of pages5
JournalAdvanced Materials
Volume26
Issue number20
DOIs
StatePublished - May 28 2014

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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