Developments in pharmacotherapy for tobacco dependence

Past, present and future

Jonathan Foulds, Michael B. Steinberg, Jill M. Williams, Douglas M. Ziedonis

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

In the mid-1970s there were no effective pharmacological treatments for tobacco dependence. The invention of nicotine gum was a major treatment advance and also greatly helped our understanding of the nature of tobacco dependence. There are now eight effective pharmacotherapies (nicotine gum, patch, nasal spray, inhaler, lozenge/tablet, bupropion, nortriptyline and clonidine) available to aid smoking cessation. Other non-nicotine agents that show promise are under investigation, including glucose, rimonabant, selegiline and varenicline. Greater knowledge of the mechanisms of action of the effective non-nicotine agents should lead to better understanding of the nature of tobacco dependence. Future research into optimal treatments should examine long-term combination pharmacotherapy combined with improved psychosocial support that is partly designed to enhance medication compliance. In addition, there is a need for studies designed to evaluate the efficacy of pharmacotherapies in populations such as youth, pregnant smokers and smokers with co-occurring mental health problems.

Original languageEnglish (US)
Pages (from-to)59-71
Number of pages13
JournalDrug and Alcohol Review
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2006

Fingerprint

Tobacco Use Disorder
nicotine
rimonabant
Drug Therapy
present
Tobacco Use Cessation Products
Nortriptyline
Nasal Sprays
Selegiline
Bupropion
Medication Adherence
Nebulizers and Vaporizers
Clonidine
Smoking Cessation
Nicotine
Tablets
Mental Health
psychosocial care
Therapeutics
Pharmacology

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Health(social science)

Cite this

Foulds, Jonathan ; Steinberg, Michael B. ; Williams, Jill M. ; Ziedonis, Douglas M. / Developments in pharmacotherapy for tobacco dependence : Past, present and future. In: Drug and Alcohol Review. 2006 ; Vol. 25, No. 1. pp. 59-71.
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Developments in pharmacotherapy for tobacco dependence : Past, present and future. / Foulds, Jonathan; Steinberg, Michael B.; Williams, Jill M.; Ziedonis, Douglas M.

In: Drug and Alcohol Review, Vol. 25, No. 1, 01.01.2006, p. 59-71.

Research output: Contribution to journalArticle

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